Endovascular Brachytherapy Using Liquid Beta-Emitting Rhenium-188 for the Treatment of Long-Segment Femoropopliteal In-Stent Stenosis

Purpose To evaluate the efficacy and safety of endovascular brachytherapy with liquid beta-emitting rhenium-188 (Re-188) in patients with long-segment in-stent stenosis in the femoropopliteal segment. Methods From July 2009 to April 2011, 90 consecutive patients (59 men; mean age 68.3±10.3 years, ra...

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Bibliographic Details
Published in:Journal of endovascular therapy 2012-08, Vol.19 (4), p.467-475
Main Authors: Werner, Martin, Scheinert, Dierk, Henn, Marcela, Scheinert, Susanne, Bräunlich, Sven, Bausback, Yvonne, Friedenberger, Josef, Schuster, Johannes, Hertting, Klaus, Piorkowski, Michael, Rosner, Christian, Schmidt, Andrej, Ulrich, Matthias, Gutberlet, Matthias
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Amputation
Angioplasty
Angioplasty, Balloon - adverse effects
Angioplasty, Balloon - instrumentation
Arterial Occlusive Diseases - diagnosis
Arterial Occlusive Diseases - physiopathology
Arterial Occlusive Diseases - radiotherapy
Arterial Occlusive Diseases - therapy
Brachytherapy - adverse effects
Brachytherapy - methods
Chi-Square Distribution
Constriction, Pathologic
Disease-Free Survival
Dissection
Drug dosages
Female
Femoral Artery - diagnostic imaging
Femoral Artery - physiopathology
Germany
Humans
Kaplan-Meier Estimate
Limb Salvage
Male
Medical imaging
Middle Aged
Popliteal Artery - diagnostic imaging
Popliteal Artery - physiopathology
Predictive Value of Tests
Radiation therapy
Radiography
Radioisotopes - adverse effects
Radioisotopes - therapeutic use
Recurrence
Retrospective Studies
Rhenium - adverse effects
Rhenium - therapeutic use
Risk Assessment
Risk Factors
Stents
Thrombosis - etiology
Time Factors
Treatment Outcome
Ultrasonic imaging
Ultrasonography, Doppler, Duplex
Vascular Patency
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Summary:Purpose To evaluate the efficacy and safety of endovascular brachytherapy with liquid beta-emitting rhenium-188 (Re-188) in patients with long-segment in-stent stenosis in the femoropopliteal segment. Methods From July 2009 to April 2011, 90 consecutive patients (59 men; mean age 68.3±10.3 years, range 43–86) with symptomatic in-stent stenosis/occlusion (24.6-cm mean lesion length) of the femoropopliteal segment underwent angioplasty and subsequent endovascular brachytherapy. The liquid beta-emitting Re-188 was applied to the target lesion within an angioplasty balloon using a dose of 13 Gy at a depth of 2 mm into the vessel wall. Clinical and angiographic follow-up data were collected up to 2 years. The main study endpoints were the 6- and 12-month primary patency rates defined as
ISSN:1526-6028
1545-1550
DOI:10.1583/12-3832R.1