Serum leptin, resistin and TNF-α levels in patients with systemic sclerosis: the role of adipokines in scleroderma

Aim Systemic sclerosis (SSc) is a chronic fibrotic collagen tissue disease. Leptin's role in regulating immune and inflammatory response has become increasingly evident. Resistin has pro‐inflammatory properties and also is associated with inflammatory markers in some rheumatologic diseases. The...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2012-08, Vol.15 (4), p.374-379
Main Authors: Pehlivan, Yavuz, Onat, Ahmet Mesut, Ceylan, Nurdan, Turkbeyler, Ibrahim Halil, Buyukhatipoglu, Hakan, Comez, Gazi, Babacan, Taner, Tarakcioglu, Mehmet
Format: Article
Language:English
Subjects:
Adult
Enzyme-Linked Immunosorbent Assay
Female
Health Status
Humans
leptin
Leptin - blood
resistin
Resistin - blood
Scleroderma, Diffuse - blood
Scleroderma, Diffuse - diagnosis
Scleroderma, Limited - blood
Scleroderma, Limited - diagnosis
Severity of Illness Index
Skin - pathology
systemic sclerosis
TNF-α
Tumor Necrosis Factor-alpha - blood
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Summary:Aim Systemic sclerosis (SSc) is a chronic fibrotic collagen tissue disease. Leptin's role in regulating immune and inflammatory response has become increasingly evident. Resistin has pro‐inflammatory properties and also is associated with inflammatory markers in some rheumatologic diseases. The purpose of this study was to determine serum leptin, resistin and tumor necrosis factor alpha (TNF‐α) in SSc patients and evaluate their association with other frequently used laboratory and clinic findings. Method Sixteen patients were compared with 30 healthy women of similar age and body mass index. Serum leptin, resistin and TNF‐α levels were measured by enzyme‐linked immunosorbent assay and results were assessed by Mann–Whitney U ‐test and Spearman's correlation test. Results Leptin levels were significantly increased in the SSc group compared to controls (7789.43 ± 1180.72 pg/mL, 1790.55 ± 333.68 pg/mL, P  0.05). Conclusion Leptin, resistin and TNF‐α levels were found to be higher in SSc in contrast to the control group. These adipokines may have differentiating roles in the pathogenesis of SSc. In order to verify these findings, further clinical studies are needed with larger patient groups.
ISSN:1756-1841
1756-185X
DOI:10.1111/j.1756-185X.2012.01755.x