Loading…

TIGECYCLINE-INDUCED ACUTE PANCREATITIS: ABOUT TWO CASES AND REVIEW OF THE LITERATURE

Tigecycline (formerly CAR-936, Tygacyl) is the first glycylcycline antibiotic available for clinical use. It has an expanded broad-spectrum antibiotic activity. Phase III studies have identified gastrointestinal side-effects, especially nausea and vomiting, as the most common adverse events. Few cas...

Full description

Saved in:
Bibliographic Details
Published in:Acta clinica belgica (English ed. Online) 2012-05, Vol.67 (3), p.229-232
Main Authors: MAROT, J.-C, JONCKHEERE, S, MUNYENTWALI, H, BELKHIR, L, VANDERCAM, B, YOMBI, J. C
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tigecycline (formerly CAR-936, Tygacyl) is the first glycylcycline antibiotic available for clinical use. It has an expanded broad-spectrum antibiotic activity. Phase III studies have identified gastrointestinal side-effects, especially nausea and vomiting, as the most common adverse events. Few cases of acute pancreatitis (AP) have been described in the literature. We report two new cases of mild tigecycline-induced pancreatitis. Tigecycline was given for soft-tissue infection in both cases. Symptoms such as nausea, vomiting and mostly abdominal pain occurred within 5 days after starting Tigecycline. Pancreatic enzymes elevation occurred five to six days after initiation of treatment, and resolved within a week after drug-discontinuation. Diagnosis of mild pancreatitis was confirmed after performing CT-Scan of the abdomen in both cases. We take this opportunity to review the literature about this potentially serious side-effect induced by tigecycline.
ISSN:1784-3286
2295-3337
DOI:10.2143/ACB.67.3.2062663