Evidence of an autochthonous Toscana virus strain in Croatia

Abstract Background Phleboviruses are large and widespread group of viruses that are transmitted by arthropods and they have been reported to circulate in endemic regions of Mediterranean Basin, including Croatia. Objectives To investigate the role of Toscana virus, as a cause of the aseptic meningi...

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Bibliographic Details
Published in:Journal of clinical virology 2012-09, Vol.55 (1), p.4-7
Main Authors: Punda-Polić, Volga, Mohar, Bojana, Duh, Darja, Bradarić, Nikola, Korva, Miša, Fajs, Luka, Saksida, Ana, Avšič-Županc, Tatjana
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergy and Immunology
Antibodies, Viral - blood
Aseptic meningitis
Biological and medical sciences
Bunyaviridae Infections - blood
Bunyaviridae Infections - diagnosis
Bunyaviridae Infections - virology
Child
Child, Preschool
Croatia
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Infectious Disease
Infectious diseases
Male
Medical sciences
Meningitis, Aseptic - blood
Meningitis, Aseptic - diagnosis
Meningitis, Aseptic - virology
Microbiology
Middle Aged
Miscellaneous
Phleboviruses
Phylogeny
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - blood
RNA, Viral - cerebrospinal fluid
Sandfly fever Naples virus - genetics
Sandfly fever Naples virus - isolation & purification
Toscana virus
Viral diseases
Virology
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Summary:Abstract Background Phleboviruses are large and widespread group of viruses that are transmitted by arthropods and they have been reported to circulate in endemic regions of Mediterranean Basin, including Croatia. Objectives To investigate the role of Toscana virus, as a cause of the aseptic meningitis, in summer months in Croatia. Study design Samples from 30 patients with aseptic meningitis were retrospectively tested by serology and RT-PCR for TOSV. Results TOSV RNA was detected in 2/30 and TOSV IgM antibodies were found in 4/30 of patients. Phylogenetic analysis of partial L and S segments suggests that TOSV from Croatia represents an autochthonous strain. Conclusions The study has confirmed the role of TOSV as an agent that causes aseptic meningitis in Croatia, therefore it should be considered by physicians when encountering meningitis or febrile illness among indigenous population or travellers during the summer months.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2012.06.006