Immune senescence and vaccines to prevent herpes zoster in older persons

Highlights ► Latent VZV is maintained in sensory neurons because of VZV-specific T-cell immunity. ► This immunity declines with age – the number/function of early effectors and effector memory. ► The loss of this T-cell immunity correlates with the occurrence of herpes zoster. ► A herpes zoster vacc...

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Bibliographic Details
Published in:Current opinion in immunology 2012-08, Vol.24 (4), p.494-500
Main Author: Levin, Myron J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - immunology
Allergy and Immunology
Animals
Herpes Zoster - prevention & control
Herpes Zoster Vaccine - immunology
Herpesvirus 3, Human - immunology
Humans
Immunity, Cellular - physiology
T-Lymphocytes - immunology
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Summary:Highlights ► Latent VZV is maintained in sensory neurons because of VZV-specific T-cell immunity. ► This immunity declines with age – the number/function of early effectors and effector memory. ► The loss of this T-cell immunity correlates with the occurrence of herpes zoster. ► A herpes zoster vaccine can restore this immunity and prevent herpes zoster. ► Suggestions are offered to improve the efficacy of zoster vaccine.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2012.06.002