Questioning the Role of a Neutropenic Diet following Hematopoetic Stem Cell Transplantation

The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract. Evidence supporting this practice is lacking, however, and the actual efficacy of the...

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Bibliographic Details
Published in:Biology of blood and marrow transplantation 2012-09, Vol.18 (9), p.1385-1390
Main Authors: Trifilio, Steven, Helenowski, Irene, Giel, Meghan, Gobel, Barbara, Pi, Judy, Greenberg, Deborah, Mehta, Jayesh
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacterial Infections - diet therapy
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Case-Control Studies
Databases, Factual
Diet
Female
Gastrointestinal Tract - drug effects
Gastrointestinal Tract - microbiology
Hematology, Oncology and Palliative Medicine
Hematopoietic Stem Cell Transplantation
Humans
Infection
Leukemia - diet therapy
Leukemia - microbiology
Leukemia - therapy
Lymphoma - diet therapy
Lymphoma - microbiology
Lymphoma - therapy
Male
Middle Aged
Multiple Myeloma - diet therapy
Multiple Myeloma - microbiology
Multiple Myeloma - therapy
Neutropenia - diet therapy
Neutropenia - microbiology
Neutropenia - therapy
Nutrition
Retrospective Studies
Transplantation, Homologous
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Summary:The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract. Evidence supporting this practice is lacking, however, and the actual efficacy of the ND remains unknown. Institutional policy at Northwestern Memorial Hospital discontinued the use of ND in 2006. We conducted a retrospective study of 726 consecutive HSCT recipients, 363 who received an ND and 363 who received a general hospital diet, to determine the incidence of microbiologically confirmed infections during and after transplantation. Our findings indicate a higher rate of infections in the HSCT recipients who received an ND.
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2012.02.015