New Fluorescent and Colorimetric Probe for Cyanide: Direct Reactivity, High Selectivity, and Bioimaging Application

Taking advantage of the special nucleophilicity of cyanide, a new ratiometric fluorescent and colorimetric probe (Coum-1) was designed by tuning the π–conjugated bridge to affect the intramolecular charge transfer efficiency. Upon the addition of CN– anion, the probe displayed very large blue-shift...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2012-08, Vol.4 (8), p.4387-4392
Main Authors: Cheng, Xiaohong, Tang, Runli, Jia, Huizhen, Feng, Jun, Qin, Jingui, Li, Zhen
Format: Article
Language:English
Subjects:
Anions
Calibration
Colorimetry - methods
Cyanides - chemistry
Ethanol - chemistry
Fluorescent Dyes - pharmacology
HeLa Cells
Humans
Magnetic Resonance Spectroscopy - methods
Microscopy, Fluorescence - methods
Models, Chemical
Molecular Conformation
Solubility
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Summary:Taking advantage of the special nucleophilicity of cyanide, a new ratiometric fluorescent and colorimetric probe (Coum-1) was designed by tuning the π–conjugated bridge to affect the intramolecular charge transfer efficiency. Upon the addition of CN– anion, the probe displayed very large blue-shift in both fluorescence (90 nm) and absorption (90 nm) spectra, with the detection limit of 800 nM. Other anions gave nearly no interference. Furthermore, Coum-1 was successfully applied to the fluorescent microscopic imaging for the detection of CN– in HeLa cells.
ISSN:1944-8244
1944-8252
DOI:10.1021/am3010412