Unusual Muscular Injury in an Infant With Severe H1N1 Infection

Abstract We report the first well-documented case of unilateral orbital myositis in an 8-month-old boy with life-threatening pandemic H1N1 infection. He presented with status epilepticus and hemodynamic failure associated with unusual right orbital myositis and acute rhabdomyolysis. Because of sever...

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Bibliographic Details
Published in:Pediatric neurology 2012-07, Vol.47 (1), p.51-54
Main Authors: Guedj, Romain, MD, Desguerre, Isabelle, MD, PhD, Brassier, Anaïs, MD, Boddaert, Nathalie, MD, PhD, Hubert, Philippe, MD, Oualha, Mehdi, MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Complications
Corticoids
Creatine Kinase - blood
Epilepsy
Etiology
Evolution
Hemodynamics
Hospitals
Humans
Infant
Infants
Infection
Influenza
Influenza A Virus, H1N1 Subtype - pathogenicity
Influenza, Human - complications
Injuries
Injuries of the nervous system and the skull. Diseases due to physical agents
Magnetic Resonance Imaging
Male
Medical sciences
Muscles
Muscular Diseases - blood
Muscular Diseases - diagnosis
Muscular Diseases - etiology
Muscular Diseases - virology
Myositis
Neurology
pandemics
Pediatrics
Rhabdomyolysis
Traumas. Diseases due to physical agents
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Summary:Abstract We report the first well-documented case of unilateral orbital myositis in an 8-month-old boy with life-threatening pandemic H1N1 infection. He presented with status epilepticus and hemodynamic failure associated with unusual right orbital myositis and acute rhabdomyolysis. Because of severe myolysis, metabolic screening was performed to exclude metabolic and genetic etiologies. After corticosteroid administration and symptomatic support, the disease evolution was favorable, without sequelae at hospital discharge. H1N1 influenza infection may be associated with multiple organ failure, and complicated by unusual muscle injury. The presence of intense myolysis should alert practitioners to potential metabolic and genetic etiologies.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2012.04.006