Synthetic membrane active amphiphiles

During the past several decades, various synthetic organic compounds that form pores in bilayer membranes have been prepared and studied. These membrane active amphiphiles have also proved to be useful in affecting the transport of molecules into or through the bilayer. This article discusses the ev...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2012-06, Vol.64 (9), p.784-796
Main Authors: Gokel, George W., Negin, Saeedeh
Format: Article
Language:English
Subjects:
Amphiphiles
Anti-Infective Agents - chemistry
Antibiotics
Biological Transport
Direct injection chemotherapy
Drug delivery
Drug Delivery Systems - methods
Humans
Hydraphiles
Lipid Bilayers - chemistry
Membranes, Artificial
Surface-Active Agents - chemistry
Synthetic ion transporters
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Summary:During the past several decades, various synthetic organic compounds that form pores in bilayer membranes have been prepared and studied. These membrane active amphiphiles have also proved to be useful in affecting the transport of molecules into or through the bilayer. This article discusses the evolution of these compounds and exemplifies recent applications such as enhancement of antimicrobial activity. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2012.01.011