Glioblastoma multiforme and cerebral cavernous malformations: intersection of pathophysiologic pathways

Abstract Cerebral cavernous malformations (CCM) are known to occur in both sporadic and familial forms. To date, there has been no identified association of CCM with glioblastoma multiforme. We present a 69-year-old woman with a 14 year history of multiple CCM who developed progressive aphasia. She...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2012-06, Vol.19 (6), p.884-886
Main Authors: Mian, Matthew K, Nahed, Brian V, Walcott, Brian P, Ogilvy, Christopher S, Curry, William T
Format: Article
Language:English
Subjects:
Aged
aphasia
Biopsy
Brain tumor
Cavernoma
Cavernous malformation
Central Nervous System Vascular Malformations - pathology
Computed tomography
Female
Gadolinium
Glioblastoma
Glioblastoma - pathology
glioblastoma multiforme
Glioma
Humans
Magnetic Resonance Imaging
Nervous system
Neurology
Radiation
Reviews
Temporal Lobe - pathology
Tumors
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Summary:Abstract Cerebral cavernous malformations (CCM) are known to occur in both sporadic and familial forms. To date, there has been no identified association of CCM with glioblastoma multiforme. We present a 69-year-old woman with a 14 year history of multiple CCM who developed progressive aphasia. She had no radiation exposure and had only undergone a single computed tomography scan in her entire life. MRI demonstrated irregular gadolinium enhancement in the area of a prior stable CCM, suspicious for a high grade tumor. Stereotactic biopsy revealed a glioblastoma multiforme. This is a unique case of glioblastoma multiforme arising from the “site” of a known CCM. We review the literature on the genetics of cavernous malformations and propose a mechanism for the tumorigenic potential of these vascular malformations.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2011.07.017