Use of chitosan in the treatment of obesity: evaluation of interaction with vitamin B2

Obesity is a serious health problem and its prevalence has increased over the years. Studies have assessed the polysaccharide chitosan as anti-obesity supplement due to its ability to absorb fats. However, this property may cause the interaction of chitosan with essential substances for the proper f...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2011-05, Vol.62 (3), p.195-199
Main Authors: Rodrigues, Máira Regina, Oliveira, Hueder Paulo M., Lacerda, Fábio Vieira
Format: Article
Language:English
Subjects:
Absorption
Aqueous solutions
Avitaminosis - etiology
Carbohydrates
chitosan
Chitosan - pharmacology
Chitosan - therapeutic use
Dietary supplements
Dietary Supplements - adverse effects
Drug Interactions
Evaluation
Fats
Fluorescence
Food science
Health (problems)
Humans
Hypolipidemic Agents - pharmacology
Hypolipidemic Agents - therapeutic use
Measurement
Nutrition
Obesity
Obesity - drug therapy
Objectives
Riboflavin
Riboflavin - metabolism
spectroscopy
Vitamin B
Vitamins
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Summary:Obesity is a serious health problem and its prevalence has increased over the years. Studies have assessed the polysaccharide chitosan as anti-obesity supplement due to its ability to absorb fats. However, this property may cause the interaction of chitosan with essential substances for the proper functioning of the body, such as vitamins. In this context, the purpose of the present study was to evaluate interactions of the chitosan with vitamin B2.These interactions were evaluated in the absence and the presence of acid aqueous solution of chitosan using fluorescence and ultraviolet-visible absorption measurements of vitamin B2.Results showed that the rigid microenvironment generated by chitosan solution modifies the photophysics properties of vitamin B2.Thus, chitosan is able to eliminate vitamin B2 and the present study aims to warn of excessive loss of vitamins or other nutrients by the body during prolonged treatment with chitosan.
ISSN:0963-7486
1465-3478
DOI:10.3109/09637486.2010.529071