Evaluation of an improved rapid neutralizing antibody detection test (RAPINA) for qualitative and semiquantitative detection of rabies neutralizing antibody in humans and dogs

Highlights ► Novel method (RAPINA) to measure rabies virus neutralizing antibody (VNA) values in the vaccinees’ sera. ► RAPINA had quite high sensitivity and specificity compared with conventional method. ► RAPINA is an easy to use and quick method which can measure the VNA values. ► RAPINA will be...

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Bibliographic Details
Published in:Vaccine 2012-06, Vol.30 (26), p.3891-3896
Main Authors: Nishizono, Akira, Yamada, Kentaro, Khawplod, Pakamatz, Shiota, Seiji, Perera, Devika, Matsumoto, Takashi, Wimalaratne, Omala, Mitui, Marcelo Takahiro, Ahmed, Kamruddin
Format: Article
Language:English
Subjects:
Adult
Agreements
Allergy and Immunology
animal health
Animals
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
antibody detection
blood serum
disease control
Dogs
Enzyme-linked immunosorbent assay
Fatalities
Female
fluorescence
Hospitals
Humans
Immunization
immunoaffinity chromatography
Immunochromatography
Immunochromatography - methods
Japan
Male
neutralization
Neutralization Tests - methods
neutralizing antibodies
people
Prophylaxis
Rabies
Rabies - immunology
Rabies - veterinary
Rabies vaccine
Rabies virus
Rabies virus - immunology
rapid methods
seroprevalence
Sri Lanka
Thailand
Vaccines
Values
Veterinary services
Virus-neutralizing antibody
World Health Organization
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Description
Summary:Highlights ► Novel method (RAPINA) to measure rabies virus neutralizing antibody (VNA) values in the vaccinees’ sera. ► RAPINA had quite high sensitivity and specificity compared with conventional method. ► RAPINA is an easy to use and quick method which can measure the VNA values. ► RAPINA will be useful and effective tool for epidemiological surveys or to determine the need for immunization in humans or animals.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.04.003