Reducing the pathogenicity of BmNPV in silkworms using silver nanoparticles

This study examined the efficacy of silver nanoparticles colloid (AgNPC) in reducing the pathogenicity of the Bombyx mori L. (Lepidoptera: Bombycidae) nuclear polyhydrosis virus (BmNPV) in silkworms. We found that the survival rate of the infected silkworms improved significantly, from 22 to 67%, fo...

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Bibliographic Details
Published in:Entomologia experimentalis et applicata 2012-09, Vol.144 (3), p.301-310
Main Authors: Ruyi, Zou, Zhenyou, Zou, Miao, Liu, Ninan, Chen, Shuoqi, Xu, Aiping, Ma, Lianwei, Zhou, Tianle, Qian, Yiqing, Zhou, Cui, Wang, Bing, Hu, Zhongyuan, Shen, Ruobing, Liang, Zhenlin, Yang, Jinhua, Xia, Liming, Hong
Format: Article
Language:English
Subjects:
Bombycidae
Bombyx mori
Bombyx mori NPV
Capsid protein
colloid
Colloids
DNA
Free radicals
Hemocytes
Lepidoptera
Nanoparticles
Nanotechnology
nuclear polyhedrosis virus
Pathogenicity
Septicemia
Silver
Survival
survival rate
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Summary:This study examined the efficacy of silver nanoparticles colloid (AgNPC) in reducing the pathogenicity of the Bombyx mori L. (Lepidoptera: Bombycidae) nuclear polyhydrosis virus (BmNPV) in silkworms. We found that the survival rate of the infected silkworms improved significantly, from 22 to 67%, following treatment with AgNPC. However, AgNPs caused clumping of hemocytes in vivo and this was associated with slight weight loss and reduced cocoon size in the treated silkworms. The adherence of silver nanoparticles to the virus or hemocytes caused them to aggregate. In addition, by catalyzing the generation of free radicals, silver nanoparticles can perforate and break up the virus capsids, proteins, and DNA of the BmNPVs, thus restraining their pathogenicity and improving the survival capacity of infected silkworms.
ISSN:0013-8703
1570-7458
DOI:10.1111/j.1570-7458.2012.01302.x