Multicentre Etest evaluation of in vitro activity of conventional antifungal drugs against European bovine mastitis Prototheca spp. isolates

Bovine mammary protothecosis is a serious pathology that entails high economic losses in the dairy industry. The disease, the frequency of which has recently been increasing worldwide, is caused by unicellular, achlorophyllous, yeast-like algae of two species: Prototheca zopfii and Prototheca blasch...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2012-08, Vol.67 (8), p.1945-1947
Main Authors: JAGIELSKI, Tomasz, BUZZINI, Pietro, SILVA, Eliane, THOMPSON, Gertrude, STACHOWIAK, Radosław, BIELECKI, Jacek, LASSA, Henryka, MALINOWSKI, Edward, BRANDA, Eva, TURCHETTI, Benedetta, POLLEICHTNER, Angela, ROESLER, Uwe, LAGNEAU, Paul-Emile, MARQUES, Sara
Format: Article
Language:English
Subjects:
Algae
Amphotericin B
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal activity
Antifungal Agents - pharmacology
azoles
Bacterial infections
Biological and medical sciences
Cattle
Cow's milk
Dairy industry
Drugs
Economics
Female
Genotype & phenotype
Genotypes
Gram-positive bacteria
Gynecology. Andrology. Obstetrics
Mammary gland diseases
Mastitis
Mastitis, Bovine - microbiology
Medical sciences
Microbial Sensitivity Tests
Minimum inhibitory concentration
Non tumoral diseases
Pharmacology
Pharmacology. Drug treatments
Prescription drugs
Prototheca
Prototheca - drug effects
Prototheca - isolation & purification
Prototheca zopfii
Protothecosis
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Summary:Bovine mammary protothecosis is a serious pathology that entails high economic losses in the dairy industry. The disease, the frequency of which has recently been increasing worldwide, is caused by unicellular, achlorophyllous, yeast-like algae of two species: Prototheca zopfii and Prototheca blaschkeae. The objective of this study was to investigate the in vitro activity of a panel of conventional antifungal drugs against Prototheca spp. isolates. A total of 144 P. zopfii genotype 2 and P. blaschkeae strains isolated from milk of mastitic cows were subjected to drug susceptibility testing by Etest methodology. Five out of ten antifungal drugs tested exhibited no activity against Prototheca spp. isolates. The best activity against Prototheca spp. was demonstrated by amphotericin B (MIC₉₀ of 1.5 mg/L). The MICs differed significantly (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dks134