Elevated content of osteopontin in plasma and tumor tissues of patients with laryngeal and hypopharyngeal carcinoma associated with metastasis and prognosis

The aim of this study was to evaluate the usefulness of osteopontin (OPN) expression level in plasma and tumor tissues of patients with laryngeal and hypopharyngeal squamous-cell carcinoma for predicting metastasis and survival of this tumor. The OPN expression in tumor tissues was detected by immun...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2012-09, Vol.29 (3), p.1429-1434
Main Authors: Li, Yong, Li, Liang, Wang, Jing Ting, Kan, Xuan, Lu, Jian Guang
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Carcinoma - metabolism
Carcinoma - mortality
Carcinoma - pathology
Enzyme-Linked Immunosorbent Assay
Female
Hematology
Humans
Hypopharyngeal Neoplasms - metabolism
Hypopharyngeal Neoplasms - mortality
Hypopharyngeal Neoplasms - pathology
Immunohistochemistry
Internal Medicine
Kaplan-Meier Estimate
Laryngeal Neoplasms - metabolism
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Metastasis - pathology
Oncology
Original Paper
Osteopontin - analysis
Osteopontin - metabolism
Pathology
Prognosis
Tissue Array Analysis
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Summary:The aim of this study was to evaluate the usefulness of osteopontin (OPN) expression level in plasma and tumor tissues of patients with laryngeal and hypopharyngeal squamous-cell carcinoma for predicting metastasis and survival of this tumor. The OPN expression in tumor tissues was detected by immunohistochemical staining in a tissue microarray of laryngeal and hypopharyngeal carcinomas, and the OPN level in plasma was measured by ELISA. The expression levels of OPN in plasma and tumor tissues were associated with clinicopathological features and survival of laryngeal and hypopharyngeal carcinomas. Results showed that the OPN expression quantitation either in tissues or plasma was significantly correlated with differentiation and lymphatic metastasis of the laryngeal and hypopharyngeal carcinoma. Elevated OPN level of plasma and tissues was significantly associated with poor survival. In conclusion, elevated OPN level in plasma and tumor tissues was significantly associated with metastasis and survival of laryngeal and hypopharyngeal carcinomas. Elevated OPN level in plasma and tumor tissues may become a useful indicator of prognosis for laryngeal and hypopharyngeal cancers.
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-011-0012-z