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Right ventricular hypertrophy with heart failure in Holstein heifers at elevation of 1,600 meters
A syndrome of progressive right-sided heart failure occurred among yearling Holsteins at a heifer-raising facility and 2 dairies on the Colorado Front Range between 2007 and 2011. Most cases were seen at the heifer-raising facility, where the disease ranked second only to pneumonia as a major cause...
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| Published in: | Journal of veterinary diagnostic investigation 2012-09, Vol.24 (5), p.867-877 |
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| Main Authors: | , , , , |
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| cites | cdi_FETCH-LOGICAL-c403t-ccc241c227875abb4c59825fdbe8d42c6e57b7a7f2c6ff03bfdcd5d5880a423b3 |
| container_end_page | 877 |
| container_issue | 5 |
| container_start_page | 867 |
| container_title | Journal of veterinary diagnostic investigation |
| container_volume | 24 |
| creator | Malherbe, Christopher R Marquard, Jana Legg, David E Cammack, Kristi M O'Toole, Donal |
| description | A syndrome of progressive right-sided heart failure occurred among yearling Holsteins at a heifer-raising facility and 2 dairies on the Colorado Front Range between 2007 and 2011. Most cases were seen at the heifer-raising facility, where the disease ranked second only to pneumonia as a major cause of death in animals aged |
| doi_str_mv | 10.1177/1040638712453580 |
| format | article |
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Most cases were seen at the heifer-raising facility, where the disease ranked second only to pneumonia as a major cause of death in animals aged <1.5 years. The disease resulted in the death or premature sale of 55 animals over the 5-year period. Affected heifers were 4-15 months old when they developed dyspnea, tachycardia, distention and pulsation of jugular veins, lethargy, and weight loss. Clinical progression in most was rapid (2 days to 2 weeks). Ten cattle with typical clinical signs were examined postmortem between 2008 and 2010. Seven developed clinical signs after transportation 57-238 days earlier from Wisconsin (elevation: < 275 m); the remaining 3 animals were born and raised at an altitude of 1,600 m. At necropsy, the 10 cattle had marked hypertrophy of right ventricular myocardium, dilated right atria, right ventricles, and pulmonary trunks, as well as hepatomegaly, ascites, and serous atrophy of fat. The principal histological change in lungs was hypertrophied tunicae adventitia and media of muscular arteries. Hepatic changes were typical of chronic passive congestion. Ultrastructural changes in heart were consistent with uncomplicated hypertrophy of cardiocytes with no evidence of primary cardiomyopathy. The syndrome most likely represents brisket disease due to pulmonary hypertension at the modest elevation of 1,600 m.</description><identifier>ISSN: 1040-6387</identifier><identifier>EISSN: 1943-4936</identifier><identifier>DOI: 10.1177/1040638712453580</identifier><identifier>PMID: 22914818</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Altitude ; Animals ; arteries ; ascites ; atrophy ; cardiomyopathy ; Cattle ; Cattle Diseases - etiology ; Cattle Diseases - pathology ; dairies ; death ; dyspnea ; Female ; heart failure ; Heart Failure - etiology ; Heart Failure - pathology ; Heart Failure - veterinary ; heifers ; Holstein ; hypertension ; hypertrophy ; Hypertrophy, Right Ventricular - etiology ; Hypertrophy, Right Ventricular - pathology ; Hypertrophy, Right Ventricular - veterinary ; Lung Diseases - veterinary ; lungs ; myocardium ; necropsy ; pneumonia ; transportation ; weight loss ; yearlings</subject><ispartof>Journal of veterinary diagnostic investigation, 2012-09, Vol.24 (5), p.867-877</ispartof><rights>2012 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-ccc241c227875abb4c59825fdbe8d42c6e57b7a7f2c6ff03bfdcd5d5880a423b3</citedby><cites>FETCH-LOGICAL-c403t-ccc241c227875abb4c59825fdbe8d42c6e57b7a7f2c6ff03bfdcd5d5880a423b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22914818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malherbe, Christopher R</creatorcontrib><creatorcontrib>Marquard, Jana</creatorcontrib><creatorcontrib>Legg, David E</creatorcontrib><creatorcontrib>Cammack, Kristi M</creatorcontrib><creatorcontrib>O'Toole, Donal</creatorcontrib><title>Right ventricular hypertrophy with heart failure in Holstein heifers at elevation of 1,600 meters</title><title>Journal of veterinary diagnostic investigation</title><addtitle>J Vet Diagn Invest</addtitle><description>A syndrome of progressive right-sided heart failure occurred among yearling Holsteins at a heifer-raising facility and 2 dairies on the Colorado Front Range between 2007 and 2011. Most cases were seen at the heifer-raising facility, where the disease ranked second only to pneumonia as a major cause of death in animals aged <1.5 years. The disease resulted in the death or premature sale of 55 animals over the 5-year period. Affected heifers were 4-15 months old when they developed dyspnea, tachycardia, distention and pulsation of jugular veins, lethargy, and weight loss. Clinical progression in most was rapid (2 days to 2 weeks). Ten cattle with typical clinical signs were examined postmortem between 2008 and 2010. Seven developed clinical signs after transportation 57-238 days earlier from Wisconsin (elevation: < 275 m); the remaining 3 animals were born and raised at an altitude of 1,600 m. At necropsy, the 10 cattle had marked hypertrophy of right ventricular myocardium, dilated right atria, right ventricles, and pulmonary trunks, as well as hepatomegaly, ascites, and serous atrophy of fat. The principal histological change in lungs was hypertrophied tunicae adventitia and media of muscular arteries. Hepatic changes were typical of chronic passive congestion. Ultrastructural changes in heart were consistent with uncomplicated hypertrophy of cardiocytes with no evidence of primary cardiomyopathy. The syndrome most likely represents brisket disease due to pulmonary hypertension at the modest elevation of 1,600 m.</description><subject>Altitude</subject><subject>Animals</subject><subject>arteries</subject><subject>ascites</subject><subject>atrophy</subject><subject>cardiomyopathy</subject><subject>Cattle</subject><subject>Cattle Diseases - etiology</subject><subject>Cattle Diseases - pathology</subject><subject>dairies</subject><subject>death</subject><subject>dyspnea</subject><subject>Female</subject><subject>heart failure</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - pathology</subject><subject>Heart Failure - veterinary</subject><subject>heifers</subject><subject>Holstein</subject><subject>hypertension</subject><subject>hypertrophy</subject><subject>Hypertrophy, Right Ventricular - etiology</subject><subject>Hypertrophy, Right Ventricular - pathology</subject><subject>Hypertrophy, Right Ventricular - veterinary</subject><subject>Lung Diseases - veterinary</subject><subject>lungs</subject><subject>myocardium</subject><subject>necropsy</subject><subject>pneumonia</subject><subject>transportation</subject><subject>weight loss</subject><subject>yearlings</subject><issn>1040-6387</issn><issn>1943-4936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kL1rHDEQxUWIiR07fapYZYqsPfo6actgkthgCPijXrTa0a3M3uosaW3uv7fMOSlSpBjmwfvNg3mEfGZwxpjW5wwkrITRjEsllIF35Ii1UjSyFav3VVe7efUPycecHwAUV5p9IIect0waZo6IvQnrsdAnnEsKbplsouNui6mkuB139DmUkY5oU6HehmlJSMNML-OUC1YxYvCYMrWF4oRPtoQ40-gp-7YCoBss1TwhB95OGT-97WNy__PH3cVlc_3719XF9-vGSRClcc5xyRzn2mhl-1461Rqu_NCjGSR3K1S611b7Kr0H0fvBDWpQxoCVXPTimHzd525TfFwwl24TssNpsjPGJXcMhKrDNK8o7FGXYs4JfbdNYWPTrkLda7Hdv8XWky9v6Uu_weHvwZ8mK9DsgWzX2D3EJc312_8Fnu55b2Nn1ynk7v6WA5MAoLVqW_ECClSJug</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Malherbe, Christopher R</creator><creator>Marquard, Jana</creator><creator>Legg, David E</creator><creator>Cammack, Kristi M</creator><creator>O'Toole, Donal</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Right ventricular hypertrophy with heart failure in Holstein heifers at elevation of 1,600 meters</title><author>Malherbe, Christopher R ; Marquard, Jana ; Legg, David E ; Cammack, Kristi M ; O'Toole, Donal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-ccc241c227875abb4c59825fdbe8d42c6e57b7a7f2c6ff03bfdcd5d5880a423b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Altitude</topic><topic>Animals</topic><topic>arteries</topic><topic>ascites</topic><topic>atrophy</topic><topic>cardiomyopathy</topic><topic>Cattle</topic><topic>Cattle Diseases - etiology</topic><topic>Cattle Diseases - pathology</topic><topic>dairies</topic><topic>death</topic><topic>dyspnea</topic><topic>Female</topic><topic>heart failure</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - pathology</topic><topic>Heart Failure - veterinary</topic><topic>heifers</topic><topic>Holstein</topic><topic>hypertension</topic><topic>hypertrophy</topic><topic>Hypertrophy, Right Ventricular - etiology</topic><topic>Hypertrophy, Right Ventricular - pathology</topic><topic>Hypertrophy, Right Ventricular - veterinary</topic><topic>Lung Diseases - veterinary</topic><topic>lungs</topic><topic>myocardium</topic><topic>necropsy</topic><topic>pneumonia</topic><topic>transportation</topic><topic>weight loss</topic><topic>yearlings</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malherbe, Christopher R</creatorcontrib><creatorcontrib>Marquard, Jana</creatorcontrib><creatorcontrib>Legg, David E</creatorcontrib><creatorcontrib>Cammack, Kristi M</creatorcontrib><creatorcontrib>O'Toole, Donal</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary diagnostic investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malherbe, Christopher R</au><au>Marquard, Jana</au><au>Legg, David E</au><au>Cammack, Kristi M</au><au>O'Toole, Donal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Right ventricular hypertrophy with heart failure in Holstein heifers at elevation of 1,600 meters</atitle><jtitle>Journal of veterinary diagnostic investigation</jtitle><addtitle>J Vet Diagn Invest</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>24</volume><issue>5</issue><spage>867</spage><epage>877</epage><pages>867-877</pages><issn>1040-6387</issn><eissn>1943-4936</eissn><abstract>A syndrome of progressive right-sided heart failure occurred among yearling Holsteins at a heifer-raising facility and 2 dairies on the Colorado Front Range between 2007 and 2011. Most cases were seen at the heifer-raising facility, where the disease ranked second only to pneumonia as a major cause of death in animals aged <1.5 years. The disease resulted in the death or premature sale of 55 animals over the 5-year period. Affected heifers were 4-15 months old when they developed dyspnea, tachycardia, distention and pulsation of jugular veins, lethargy, and weight loss. Clinical progression in most was rapid (2 days to 2 weeks). Ten cattle with typical clinical signs were examined postmortem between 2008 and 2010. Seven developed clinical signs after transportation 57-238 days earlier from Wisconsin (elevation: < 275 m); the remaining 3 animals were born and raised at an altitude of 1,600 m. At necropsy, the 10 cattle had marked hypertrophy of right ventricular myocardium, dilated right atria, right ventricles, and pulmonary trunks, as well as hepatomegaly, ascites, and serous atrophy of fat. The principal histological change in lungs was hypertrophied tunicae adventitia and media of muscular arteries. Hepatic changes were typical of chronic passive congestion. Ultrastructural changes in heart were consistent with uncomplicated hypertrophy of cardiocytes with no evidence of primary cardiomyopathy. The syndrome most likely represents brisket disease due to pulmonary hypertension at the modest elevation of 1,600 m.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>22914818</pmid><doi>10.1177/1040638712453580</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1040-6387 |
| ispartof | Journal of veterinary diagnostic investigation, 2012-09, Vol.24 (5), p.867-877 |
| issn | 1040-6387 1943-4936 |
| language | eng |
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| source | SAGE |
| subjects | Altitude Animals arteries ascites atrophy cardiomyopathy Cattle Cattle Diseases - etiology Cattle Diseases - pathology dairies death dyspnea Female heart failure Heart Failure - etiology Heart Failure - pathology Heart Failure - veterinary heifers Holstein hypertension hypertrophy Hypertrophy, Right Ventricular - etiology Hypertrophy, Right Ventricular - pathology Hypertrophy, Right Ventricular - veterinary Lung Diseases - veterinary lungs myocardium necropsy pneumonia transportation weight loss yearlings |
| title | Right ventricular hypertrophy with heart failure in Holstein heifers at elevation of 1,600 meters |
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