Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats

• Published in: Atherosclerosis 2012-09, Vol.224 (1), p.136-142
• Main Authors: da Luz, Protásio L, Tanaka, Leonardo, Brum, Patrícia Chakur, Dourado, Paulo Magno Martins, Favarato, Desidério, Krieger, José Eduardo, Laurindo, Francisco Rafael M
• Format: Article
• Language: English
• Subjects: Aging; Aging - drug effects; Animals; Aorta - metabolism; atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; biomarkers; Blood and lymphatic vessels; Blood Vessels - physiology; Cardiology. Vascular system; Cardiovascular; Endocrinopathies; Endothelium-Dependent Relaxing Factors - metabolism; exercise; Exercise Test; long term effects; longevity; Longevity - drug effects; Male; Medical sciences; Non tumoral diseases. Target tissue resistance. Benign neoplasms; p16; p53; Polyphenols; Rats; Rats, Wistar; Red wine; red wines; Resveratrol; risk factors; Senescence; Stilbenes - administration & dosage; telomerase; Telomere - metabolism; Telomeres; Thyroid. Thyroid axis (diseases); Tumor Suppressor Protein p53 - metabolism; Vascular aging; Wine
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2012.06.007

Abstract Objective To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to ∼0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow. Background Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors. Methods Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow. Results Expressions of p53 decreased ∼50% ∼with RW and LRS ( p