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Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats
Abstract Objective To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to ∼0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow. Background Both RW and RS exhibit cardioprotection. RS extends lifespan in obes...
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| Published in: | Atherosclerosis 2012-09, Vol.224 (1), p.136-142 |
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| creator | da Luz, Protásio L Tanaka, Leonardo Brum, Patrícia Chakur Dourado, Paulo Magno Martins Favarato, Desidério Krieger, José Eduardo Laurindo, Francisco Rafael M |
| description | Abstract Objective To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to ∼0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow. Background Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors. Methods Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow. Results Expressions of p53 decreased ∼50% ∼with RW and LRS ( p |
| doi_str_mv | 10.1016/j.atherosclerosis.2012.06.007 |
| format | article |
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Background Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors. Methods Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow. Results Expressions of p53 decreased ∼50% ∼with RW and LRS ( p < 0.05 vs. C), p16 by ∼29% with RW ( p < 0.05 vs. C) and p21 was unaltered. RW and LRS increased telomere length >6.5-fold vs. C, and telomerase activity increased with LRS and HRS. All treatments increased aerobic capacity (C 32.5 ± 1.2, RW 38.7 ± 1.7, LRS 38.5 ± 1.6, HRS 38.3 ± 1.8 mlO2 min−1 kg−1 ), and RW or LRS also improved time of exercise tolerance vs. C ( p < 0.05). Endothelium-dependent relaxation improved with all treatments vs. C. Life span, however, was unaltered with each treatment vs. C = 673 ± 30 days, p = NS. Conclusions RW and LRS can preserve vascular function indexes in normal rats, although not extending life span. These effects were translated into better aerobic performance and exercise capacity.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2012.06.007</identifier><identifier>PMID: 22818625</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Aging ; Aging - drug effects ; Animals ; Aorta - metabolism ; atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; biomarkers ; Blood and lymphatic vessels ; Blood Vessels - physiology ; Cardiology. Vascular system ; Cardiovascular ; Endocrinopathies ; Endothelium-Dependent Relaxing Factors - metabolism ; exercise ; Exercise Test ; long term effects ; longevity ; Longevity - drug effects ; Male ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; p16 ; p53 ; Polyphenols ; Rats ; Rats, Wistar ; Red wine ; red wines ; Resveratrol ; risk factors ; Senescence ; Stilbenes - administration & dosage ; telomerase ; Telomere - metabolism ; Telomeres ; Thyroid. Thyroid axis (diseases) ; Tumor Suppressor Protein p53 - metabolism ; Vascular aging ; Wine</subject><ispartof>Atherosclerosis, 2012-09, Vol.224 (1), p.136-142</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2012 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-4e829bea9fb908879747a33a9e7eb2823d501e07f0e08bab42f5e16676ec2743</citedby><cites>FETCH-LOGICAL-c498t-4e829bea9fb908879747a33a9e7eb2823d501e07f0e08bab42f5e16676ec2743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26336635$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22818625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Luz, Protásio L</creatorcontrib><creatorcontrib>Tanaka, Leonardo</creatorcontrib><creatorcontrib>Brum, Patrícia Chakur</creatorcontrib><creatorcontrib>Dourado, Paulo Magno Martins</creatorcontrib><creatorcontrib>Favarato, Desidério</creatorcontrib><creatorcontrib>Krieger, José Eduardo</creatorcontrib><creatorcontrib>Laurindo, Francisco Rafael M</creatorcontrib><title>Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Objective To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to ∼0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow. Background Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors. Methods Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow. Results Expressions of p53 decreased ∼50% ∼with RW and LRS ( p < 0.05 vs. C), p16 by ∼29% with RW ( p < 0.05 vs. C) and p21 was unaltered. RW and LRS increased telomere length >6.5-fold vs. C, and telomerase activity increased with LRS and HRS. All treatments increased aerobic capacity (C 32.5 ± 1.2, RW 38.7 ± 1.7, LRS 38.5 ± 1.6, HRS 38.3 ± 1.8 mlO2 min−1 kg−1 ), and RW or LRS also improved time of exercise tolerance vs. C ( p < 0.05). Endothelium-dependent relaxation improved with all treatments vs. C. Life span, however, was unaltered with each treatment vs. C = 673 ± 30 days, p = NS. Conclusions RW and LRS can preserve vascular function indexes in normal rats, although not extending life span. These effects were translated into better aerobic performance and exercise capacity.</description><subject>Aging</subject><subject>Aging - drug effects</subject><subject>Animals</subject><subject>Aorta - metabolism</subject><subject>atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Vessels - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Endocrinopathies</subject><subject>Endothelium-Dependent Relaxing Factors - metabolism</subject><subject>exercise</subject><subject>Exercise Test</subject><subject>long term effects</subject><subject>longevity</subject><subject>Longevity - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>p16</subject><subject>p53</subject><subject>Polyphenols</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Red wine</subject><subject>red wines</subject><subject>Resveratrol</subject><subject>risk factors</subject><subject>Senescence</subject><subject>Stilbenes - administration & dosage</subject><subject>telomerase</subject><subject>Telomere - metabolism</subject><subject>Telomeres</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Vascular aging</subject><subject>Wine</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNksFu1DAQQCMEokvhF8CXSlwSbCexnQNIqIKCVAmJlrM1cSZbL157aycLy9fjaJceeuJiy9abGfvNFMUFoxWjTLzbVDDdYQzJuGW1qeKU8YqKilL5pFgxJbuSNap5Wqwo5azsWEvPihcpbSiljWTqeXHGuWJK8HZV_PmOA_llPRLwA8H72e7BoZ9IiODI7g7iFkxwYW1NPg8hYSJhJBHTHiNMMeRLdHAge0hmdhAJrK1fk36eMk18mAj-njDndnZEknbgifUkh6aXxbMRXMJXp_28uP386fbyS3n97err5cfr0jSdmsoGFe96hG7sO6ry72Qjoa6hQ4k9V7weWsqQypEiVT30DR9bZEJIgYbLpj4v3h7T7mK4nzFNemuTQefAY5iTZrRuGW1a0Wb0_RE12WyKOOpdtFuIhwzpxb7e6Ef29WJfU6Gz_Rz_-lRq7rc4PET_052BixOQbYEbI3iTczxwoq6FqBfuzZEbIWhYx8z8uMmV2qWFSqql1NWRwGxubzHqZCx6g4ONaCY9BPvfj_7wKJNx1i_t_okHTJswR5_bo5lOOUbfLEO1zBTjNJuTsv4Lpl_MWw</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>da Luz, Protásio L</creator><creator>Tanaka, Leonardo</creator><creator>Brum, Patrícia Chakur</creator><creator>Dourado, Paulo Magno Martins</creator><creator>Favarato, Desidério</creator><creator>Krieger, José Eduardo</creator><creator>Laurindo, Francisco Rafael M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats</title><author>da Luz, Protásio L ; Tanaka, Leonardo ; Brum, Patrícia Chakur ; Dourado, Paulo Magno Martins ; Favarato, Desidério ; Krieger, José Eduardo ; Laurindo, Francisco Rafael M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-4e829bea9fb908879747a33a9e7eb2823d501e07f0e08bab42f5e16676ec2743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aging</topic><topic>Aging - drug effects</topic><topic>Animals</topic><topic>Aorta - metabolism</topic><topic>atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Vessels - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Endocrinopathies</topic><topic>Endothelium-Dependent Relaxing Factors - metabolism</topic><topic>exercise</topic><topic>Exercise Test</topic><topic>long term effects</topic><topic>longevity</topic><topic>Longevity - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>p16</topic><topic>p53</topic><topic>Polyphenols</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Red wine</topic><topic>red wines</topic><topic>Resveratrol</topic><topic>risk factors</topic><topic>Senescence</topic><topic>Stilbenes - administration & dosage</topic><topic>telomerase</topic><topic>Telomere - metabolism</topic><topic>Telomeres</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Vascular aging</topic><topic>Wine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Luz, Protásio L</creatorcontrib><creatorcontrib>Tanaka, Leonardo</creatorcontrib><creatorcontrib>Brum, Patrícia Chakur</creatorcontrib><creatorcontrib>Dourado, Paulo Magno Martins</creatorcontrib><creatorcontrib>Favarato, Desidério</creatorcontrib><creatorcontrib>Krieger, José Eduardo</creatorcontrib><creatorcontrib>Laurindo, Francisco Rafael M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Luz, Protásio L</au><au>Tanaka, Leonardo</au><au>Brum, Patrícia Chakur</au><au>Dourado, Paulo Magno Martins</au><au>Favarato, Desidério</au><au>Krieger, José Eduardo</au><au>Laurindo, Francisco Rafael M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>224</volume><issue>1</issue><spage>136</spage><epage>142</epage><pages>136-142</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Objective To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to ∼0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow. Background Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors. Methods Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow. Results Expressions of p53 decreased ∼50% ∼with RW and LRS ( p < 0.05 vs. C), p16 by ∼29% with RW ( p < 0.05 vs. C) and p21 was unaltered. RW and LRS increased telomere length >6.5-fold vs. C, and telomerase activity increased with LRS and HRS. All treatments increased aerobic capacity (C 32.5 ± 1.2, RW 38.7 ± 1.7, LRS 38.5 ± 1.6, HRS 38.3 ± 1.8 mlO2 min−1 kg−1 ), and RW or LRS also improved time of exercise tolerance vs. C ( p < 0.05). Endothelium-dependent relaxation improved with all treatments vs. C. Life span, however, was unaltered with each treatment vs. C = 673 ± 30 days, p = NS. Conclusions RW and LRS can preserve vascular function indexes in normal rats, although not extending life span. These effects were translated into better aerobic performance and exercise capacity.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>22818625</pmid><doi>10.1016/j.atherosclerosis.2012.06.007</doi><tpages>7</tpages></addata></record> |
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| subjects | Aging Aging - drug effects Animals Aorta - metabolism atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences biomarkers Blood and lymphatic vessels Blood Vessels - physiology Cardiology. Vascular system Cardiovascular Endocrinopathies Endothelium-Dependent Relaxing Factors - metabolism exercise Exercise Test long term effects longevity Longevity - drug effects Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms p16 p53 Polyphenols Rats Rats, Wistar Red wine red wines Resveratrol risk factors Senescence Stilbenes - administration & dosage telomerase Telomere - metabolism Telomeres Thyroid. Thyroid axis (diseases) Tumor Suppressor Protein p53 - metabolism Vascular aging Wine |
| title | Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats |
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