Longitudinal changes in social functioning in mildly disabled patients with relapsing—remitting multiple sclerosis receiving subcutaneous interferon β-1a: results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study (II)

• Published in: Quality of life research 2012-09, Vol.21 (7), p.1111-1121
• Main Authors: Patti, Francesco, Amato, Maria Pia, Trojano, Maria, Bastianello, Stefano, Tola, Maria Rosalia, Picconi, Orietta, Cilia, Sabina, Cottone, Salvatore, Grimaldi, Luigi M. E.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; CLINICAL AND POLICY APPLICATIONS; Clinical Trials as Topic; Cognition; Cognitive impairment; Disabilities; Disabled Persons - psychology; Fatigue; Female; Humans; Immunologic Factors - therapeutic use; Interferon beta-1a; Interferon-beta - therapeutic use; Interferons; Interpersonal Relations; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Middle Aged; Multiple sclerosis; Multiple Sclerosis, Relapsing-Remitting - complications; Multiple Sclerosis, Relapsing-Remitting - drug therapy; Multiple Sclerosis, Relapsing-Remitting - physiopathology; Neurology; Public Health; Quality of Life; Quality of Life Research; Relapsing remitting multiple sclerosis; Sociology; Transportation; Treatment Outcome; Volunteer labor; Young Adult
• ISSN: 0962-9343; 1573-2649
• DOI: 10.1007/s11136-011-0021-6

Purpose To report longitudinal changes in and explore the influence of cognition on social functioning in mildly disabled patients with relapsing—remitting multiple sclerosis (RRMS). Methods Italian patients (18–50 years) with RRMS and Expanded Disability Status Scale (EDSS) score ≤4.0 were assigned to interferon β-1a, 44 or 22 μg subcutaneously three times weekly, and underwent annual assessments for social functioning (Environmental Status Scale [ESS]) over 3 years. Results Baseline total ESS score did not differ between patients with and without cognitive impairment (P = 0.505). Total ESS score remained low (