The fifth neurohypophysial hormone receptor is structurally related to the V2-type receptor but functionally similar to V1-type receptors

Highlights ► We cloned neurohypophysial hormone receptors from the holocephalan elephant fish. ► Elephant fish possesses four functional receptors, including a newly identified V2bR. ► V2bR is similar to V2aR (conventional V2R) in sequence, but use Ca2+ for signaling. ► V2bR was also found in teleos...

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Bibliographic Details
Published in:General and comparative endocrinology 2012-09, Vol.178 (3), p.519-528
Main Authors: Yamaguchi, Yoko, Kaiya, Hiroyuki, Konno, Norifumi, Iwata, Eri, Miyazato, Mikiya, Uchiyama, Minoru, Bell, Justin D, Toop, Tes, Donald, John A, Brenner, Sydney, Venkatesh, Byrappa, Hyodo, Susumu
Format: Article
Language:English
Subjects:
Animals
brain
calcium
Cartilaginous fish
Endocrinology & Metabolism
Evolution, Molecular
Female
fish
Fishes
G protein-coupled receptor
heart
homeostasis
hormone receptors
kidneys
Male
mammals
Molecular evolution
Neurohypophysial hormone
oxytocin
Phylogeny
Pituitary Hormones, Posterior - genetics
Pituitary Hormones, Posterior - metabolism
Receptors, G-Protein-Coupled - classification
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
Receptors, Vasopressin - classification
Receptors, Vasopressin - genetics
Receptors, Vasopressin - metabolism
reproduction
screening
Synteny
vasopressin
Vasotocin
Vasotocin - metabolism
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Summary:Highlights ► We cloned neurohypophysial hormone receptors from the holocephalan elephant fish. ► Elephant fish possesses four functional receptors, including a newly identified V2bR. ► V2bR is similar to V2aR (conventional V2R) in sequence, but use Ca2+ for signaling. ► V2bR was also found in teleosts and tetrapods. ► Synteny and phylogenetic analyses drew a new evolutionary story of the receptors.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2012.07.008