Sjögren’s syndrome at the crossroad of polyautoimmunity

• Published in: Journal of autoimmunity 2012-09, Vol.39 (3), p.199-205
• Main Authors: Amador-Patarroyo, Manuel J, Arbelaez, Juan Guillermo, Mantilla, Ruben D, Rodriguez-Rodriguez, Alberto, Cárdenas-Roldán, Jorge, Pineda-Tamayo, Ricardo, Guarin, Mayra R, Kleine, Liliana Lopez, Rojas-Villarraga, Adriana, Anaya, Juan-Manuel
• Format: Article
• Language: English
• Subjects: Abortion; Abortion, Spontaneous - immunology; Adult; Allergy and Immunology; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - immunology; Autoantibodies - blood; Autoantibodies - immunology; Autoimmune disease; Cross-Sectional Studies; Female; Humans; Inflammatory Bowel Diseases - blood; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - immunology; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - immunology; Male; Middle Aged; Multiple autoimmune syndrome; Polyautoimmunity; Pregnancy; Regression Analysis; Risk Factors; Sjogren's Syndrome - blood; Sjogren's Syndrome - complications; Sjogren's Syndrome - immunology; Sjögren’s syndrome; Smoking; Smoking - immunology; Thyroiditis, Autoimmune - blood; Thyroiditis, Autoimmune - complications; Thyroiditis, Autoimmune - immunology
• ISSN: 0896-8411; 1095-9157
• DOI: 10.1016/j.jaut.2012.05.008

Abstract The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren’s syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases.