Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients

Introduction Vitamin D is responsible for the regulation of certain genes at the transcription level, via interaction with the vitamin D receptor, and influences host immune responses and aspects of bone development, growth, and homeostasis. Our aim was to investigate the association of T a q I vita...

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Published in:American journal of orthodontics and dentofacial orthopedics 2012-09, Vol.142 (3), p.339-347
Main Authors: Fontana, Maria Luiza S. Simas Netta, de Souza, Cleber Machado, Bernardino, José Fabio, Hoette, Felix, Hoette, Maura Levi, Thum, Lotario, Ozawa, Terumi O, Capelozza Filho, Leopoldino, Olandoski, Marcia, Trevilatto, Paula Cristina
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Chi-Square Distribution
Child
Cytidine - genetics
Dental Stress Analysis
Dentistry
Female
Humans
Incisor - anatomy & histology
Logistic Models
Male
Malocclusion, Angle Class II - therapy
Medical sciences
Odontometry
Orthodontic Appliances - adverse effects
Otorhinolaryngology. Stomatology
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Receptors, Calcitriol - genetics
Root Resorption - etiology
Root Resorption - genetics
Tooth Root - anatomy & histology
Young Adult
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Summary:Introduction Vitamin D is responsible for the regulation of certain genes at the transcription level, via interaction with the vitamin D receptor, and influences host immune responses and aspects of bone development, growth, and homeostasis. Our aim was to investigate the association of T a q I vitamin D receptor gene polymorphism with external apical root resorption during orthodontic treatment. Methods Our subjects were 377 patients with Class II Division 1 malocclusion, divided into 3 groups: (1) 160 with external apical root resorption ≤1.43 mm, (2) 179 with external apical root resorption >1.43 mm), and (3) 38 untreated subjects. External apical root resorption of the maxillary incisors was evaluated on periapical radiographs taken before and after 6 months of treatment. After DNA collection and purification, vitamin D receptor T a q I polymorphism analysis was performed by polymerase chain reaction-restriction fragment length polymorphism. Univariate and multivariate analyses were performed to verify the association of clinical and genetic variables with external apical root resorption ( P  
ISSN:0889-5406
1097-6752
DOI:10.1016/j.ajodo.2012.04.013