Ternifolide A, a New Diterpenoid Possessing a Rare Macrolide Motif from Isodon ternifolius

Ternifolide A (1), a new diterpenoid featuring a unique 10-membered lactone ring formed between C-6 and C-15, along with ternifolide B (2), a nor-diterpenoid, and ternifolide C (3) were isolated from the leaves of Isodon ternifolius. Both H-8 and H-9 being α-orientations in compound 1 were found for...

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Bibliographic Details
Published in:Organic letters 2012-06, Vol.14 (12), p.3210-3213
Main Authors: Zou, Juan, Du, Xue, Pang, Guo, Shi, Yi-Ming, Wang, Wei-Guang, Zhan, Rui, Kong, Ling-Mei, Li, Xiao-Nian, Li, Yan, Pu, Jian-Xin, Sun, Han-Dong
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Cell Survival - drug effects
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Humans
Isodon - chemistry
Macrolides - chemistry
Models, Molecular
Molecular Conformation
Plant Leaves - chemistry
Terpenes - chemistry
Terpenes - isolation & purification
Terpenes - pharmacology
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Summary:Ternifolide A (1), a new diterpenoid featuring a unique 10-membered lactone ring formed between C-6 and C-15, along with ternifolide B (2), a nor-diterpenoid, and ternifolide C (3) were isolated from the leaves of Isodon ternifolius. Both H-8 and H-9 being α-orientations in compound 1 were found for the first time. The absolute configurations of 1 and 3 were confirmed by X-ray diffraction study. Compounds 1 and 3 were evaluated for their cytotoxicity.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol3013205