Rhodium-Catalyzed Asymmetric Formal Cycloadditions of Racemic Butadiene Monoxide with Imines

A simple chiral sulfur−alkene hybrid ligand has proven to be highly effective for rhodium-catalyzed formal cycloaddition reactions of racemic butadiene monoxide and imines to furnish spirooxindole oxazolidines or 1,3-oxazolidines with high yields and stereoselectivities. A possible dynamic kinetic r...

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Bibliographic Details
Published in:Organic letters 2012-06, Vol.14 (12), p.3154-3157
Main Authors: Liu, Zhaoqun, Feng, Xiangqing, Du, Haifeng
Format: Article
Language:English
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Summary:A simple chiral sulfur−alkene hybrid ligand has proven to be highly effective for rhodium-catalyzed formal cycloaddition reactions of racemic butadiene monoxide and imines to furnish spirooxindole oxazolidines or 1,3-oxazolidines with high yields and stereoselectivities. A possible dynamic kinetic resolution as well as a kinetic resolution is considered to be involved in this catalytic process.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol301248d