Influence of smoking on interleukin-1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment

• Published in: Journal of periodontal research 2012-10, Vol.47 (5), p.572-577
• Main Authors: Toker, Hulya, Akpınar, Aysun, Aydın, Huseyin, Poyraz, Omer
• Format: Article
• Language: English
• Subjects: Adult; Antioxidants - analysis; Benzothiazoles; Biological and medical sciences; Chromogenic Compounds; Chronic Periodontitis - metabolism; Chronic Periodontitis - therapy; Colorimetry - methods; crevicular fluid; Dental Plaque Index; Dental Scaling - methods; Dentistry; Dianisidine; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Fluorescent Dyes; Follow-Up Studies; Gingival Crevicular Fluid - chemistry; Gingival Hemorrhage - metabolism; Gingival Hemorrhage - therapy; Humans; IL-1; Indicators and Reagents; Interleukin-1beta - analysis; Male; Medical sciences; Non tumoral diseases; Oral Hygiene; Otorhinolaryngology. Stomatology; Oxidants - chemistry; Oxidation-Reduction; Periodontal Attachment Loss - metabolism; Periodontal Attachment Loss - therapy; Periodontal Index; Periodontal Pocket - metabolism; Periodontal Pocket - therapy; periodontitis; Phenols; Root Planing - methods; smoking; Smoking - metabolism; Sulfonic Acids; Sulfoxides; Tobacco, tobacco smoking; total antioxidant status; total oxidant status; Toxicology
• ISSN: 0022-3484; 1600-0765
• DOI: 10.1111/j.1600-0765.2012.01468.x

Toker H, Akpınar A, Aydın H, Poyraz O. Influence of smoking on interleukin‐1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodont Res 2012; 47: 572–577. © 2012 John Wiley & Sons A/S Background and Objective:  The aim of this study was to evaluate the impact of smoking on the relationship between interleukin‐1 (IL‐1β) and oxidation in patients with periodontitis and response to nonsurgical periodontal therapy. Material and Methods:  Data were obtained from 30 patients with generalized chronic periodontitis (15 smokers and 15 nonsmokers) and from 10 periodontally healthy controls. IL‐1β level, total oxidant status (TOS) and total antioxidant status (TAS) were recorded in gingival crevicular fluid. Probing depth, clinical attachment level, gingival and plaque indices and bleeding on probing were also measured. The gingival crevicular fluid and clinical parameters were recorded at baseline and 6 wk after periodontal treatment. Results:  The study showed statistically significant improvement of clinical parameters in both smokers and nonsmokers after periodontal treatment. Moreover, the baseline IL‐1β levels were significantly higher in smokers compared with nonsmokers (p