Assessment of Tamsulosin as a Potential Male Contraceptive in Healthy Volunteers

Objective To investigate the efficacy and safety of tamsulosin, an α1A -adrenoceptor antagonist, as a potential male contraceptive. Methods Forty healthy male volunteers were equally divided into 2 groups, each of which received placebo and tamsulosin sequentially in a crossover manner. Ejaculatory...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2012-09, Vol.80 (3), p.614-617
Main Authors: Wang, Jin, Zhao, Yong, Jiang, Shao-bo, Xia, Qing-hua, Wei, Chun-xiao, Wang, Mu-wen, Sun, Peng, Jin, Xun-bo
Format: Article
Language:English
Subjects:
Adrenergic alpha-1 Receptor Antagonists
Adult
Biological and medical sciences
Contraceptive Agents, Male
Cross-Over Studies
Humans
Male
Medical sciences
Nephrology. Urinary tract diseases
Single-Blind Method
Sulfonamides
Urology
Young Adult
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Summary:Objective To investigate the efficacy and safety of tamsulosin, an α1A -adrenoceptor antagonist, as a potential male contraceptive. Methods Forty healthy male volunteers were equally divided into 2 groups, each of which received placebo and tamsulosin sequentially in a crossover manner. Ejaculatory profile was examined 4 to 6 hours after administration and adverse effects were noted. Results Anejaculation occurred in all subjects after taking 0.8-mg of tamsulosin. Total functional sperm count was significantly reduced in subjects after taking 0.4-mg of tamsulosin. Six subjects receiving 0.8-mg of tamsulosin complained of tolerated discomfort, which disappeared 10 hours after administration. Conclusion When administered at 0.8 mg, tamsulosin can cause anejaculation with some transient side effects. Our results imply that tamsulosin and related drugs might potentially be used as male contraceptive agents in the future, which needs more studies to verify.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2012.06.003