Characteristics of protein variants in trichlorphon-resistant Bactrocera dorsalis (Diptera; Tephritidae) larvae

Functional proteins in larvae of Bactrocera dorsalis, a major fruit pest, play a central role in their resistance to organophosphorus insecticides. Changes in proteins in B. dorsalis larvae after trichlorphon treatment may have a role in the resistance response to trichlorphon. We analyzed 14 protei...

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Bibliographic Details
Published in:Genetics and molecular research 2012-01, Vol.11 (3), p.2608-2619
Main Authors: Jin, T, Zeng, L, Lin, Y-Y, Lu, Y-Y, Liang, G-W
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Electrophoresis, Gel, Two-Dimensional
Insect Proteins - chemistry
Insect Proteins - classification
Insect Proteins - metabolism
Insecticide Resistance - drug effects
Insecticides - pharmacology
Larva - drug effects
Larva - metabolism
Molecular Sequence Data
Mutant Proteins - chemistry
Mutant Proteins - classification
Mutant Proteins - metabolism
Tephritidae - drug effects
Tephritidae - metabolism
Trichlorfon - pharmacology
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Summary:Functional proteins in larvae of Bactrocera dorsalis, a major fruit pest, play a central role in their resistance to organophosphorus insecticides. Changes in proteins in B. dorsalis larvae after trichlorphon treatment may have a role in the resistance response to trichlorphon. We analyzed 14 protein spots of crude proteins from B. dorsalis larvae post-treatment with trichlorphon in two-dimensional gel electrophoresis through mass spectrometry and protein sequencing. We found functional proteins that are responsible for signal transduction (pkaap and dual specificity tyrosine-phosphorylation-regulated kinase), immunity (hemolectin), synthesis and decomposition (twinstar, cathepsin B, RE66325p), oxidative stress metabolism (glutathione S transferase and CG7320), energy metabolism (Act57B), and cytoskeleton formation (actin). These proteins appear to be involved in the resistance response to trichlorphon.
ISSN:1676-5680
1676-5680
DOI:10.4238/2012.July.10.12