Molecular Logic Gates for DNA Analysis: Detection of Rifampin Resistance in M. tuberculosis DNA

Elementary, Dr. Watson! A combination of YES and OR logic gates was applied to differentiate between DNA sequences of wild‐type and rifampin‐resistant (Rifr) Mycobacterium tuberculosis (Mtb) in a multiplex real‐time fluorescent assay.

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-09, Vol.51 (36), p.9075-9077
Main Authors: Cornett, Evan M., Campbell, Eleanor A., Gulenay, George, Peterson, Evan, Bhaskar, Neha, Kolpashchikov, Dmitry M.
Format: Article
Language:English
Subjects:
Antibiotics, Antitubercular - pharmacology
DNA logic gates
DNA, Bacterial - analysis
Drug Resistance, Bacterial - drug effects
molecular beacon probes
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Polymerase Chain Reaction
rifampin
Rifampin - pharmacology
SNP analysis
Spectrometry, Fluorescence
tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Elementary, Dr. Watson! A combination of YES and OR logic gates was applied to differentiate between DNA sequences of wild‐type and rifampin‐resistant (Rifr) Mycobacterium tuberculosis (Mtb) in a multiplex real‐time fluorescent assay.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203708