Molecular Logic Gates for DNA Analysis: Detection of Rifampin Resistance in M. tuberculosis DNA

Elementary, Dr. Watson! A combination of YES and OR logic gates was applied to differentiate between DNA sequences of wild‐type and rifampin‐resistant (Rifr) Mycobacterium tuberculosis (Mtb) in a multiplex real‐time fluorescent assay.

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Published in:Angewandte Chemie International Edition 2012-09, Vol.51 (36), p.9075-9077
Main Authors: Cornett, Evan M., Campbell, Eleanor A., Gulenay, George, Peterson, Evan, Bhaskar, Neha, Kolpashchikov, Dmitry M.
Format: Article
Language:English
Subjects:
Antibiotics, Antitubercular - pharmacology
DNA logic gates
DNA, Bacterial - analysis
Drug Resistance, Bacterial - drug effects
molecular beacon probes
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Polymerase Chain Reaction
rifampin
Rifampin - pharmacology
SNP analysis
Spectrometry, Fluorescence
tuberculosis
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cited_by cdi_FETCH-LOGICAL-c4238-4efb4c43830de14e2570fabd637dc35b966a8868fd6982496410bdd64bfae7a63
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container_end_page 9077
container_issue 36
container_start_page 9075
container_title Angewandte Chemie International Edition
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creator Cornett, Evan M.
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Gulenay, George
Peterson, Evan
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description Elementary, Dr. Watson! A combination of YES and OR logic gates was applied to differentiate between DNA sequences of wild‐type and rifampin‐resistant (Rifr) Mycobacterium tuberculosis (Mtb) in a multiplex real‐time fluorescent assay.
doi_str_mv 10.1002/anie.201203708
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subjects Antibiotics, Antitubercular - pharmacology
DNA logic gates
DNA, Bacterial - analysis
Drug Resistance, Bacterial - drug effects
molecular beacon probes
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Polymerase Chain Reaction
rifampin
Rifampin - pharmacology
SNP analysis
Spectrometry, Fluorescence
tuberculosis
title Molecular Logic Gates for DNA Analysis: Detection of Rifampin Resistance in M. tuberculosis DNA
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