Clinical Implications of an Implantable Cardioverter-Defibrillator in Patients With Vasospastic Angina and Lethal Ventricular Arrhythmia

• Published in: Journal of the American College of Cardiology 2012-09, Vol.60 (10), p.908-913
• Main Authors: Matsue, Yuya, MD, Suzuki, Makoto, MD, PhD, Nishizaki, Mitsuhiro, MD, PhD, Hojo, Rintaro, MD, Hashimoto, Yuji, MD, PhD, Sakurada, Harumizu, MD, PhD
• Format: Article
• Language: English
• Subjects: Acetylcholine; Adult; Aged; Angina pectoris; Angina Pectoris, Variant - diagnosis; Angina Pectoris, Variant - etiology; Angina Pectoris, Variant - therapy; Asian Continental Ancestry Group; Biological and medical sciences; Cardiac arrhythmia; Cardiac dysrhythmias; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cholinergic Agents; Coronary heart disease; Death, Sudden, Cardiac - etiology; Death, Sudden, Cardiac - prevention & control; Defibrillators, Implantable; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Heart; Heart Arrest - complications; Heart Arrest - etiology; Heart Arrest - prevention & control; Heart attacks; Humans; implantable cardioverter-defibrillator; Internal Medicine; Japan; Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Sample Size; Tachycardia, Ventricular - complications; Tachycardia, Ventricular - diagnosis; Tachycardia, Ventricular - therapy; vasospastic angina; ventricular arrhythmia
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2012.03.070

Objectives The present study was performed to investigate the clinical implications of an implantable cardioverter-defibrillator (ICD) in patients with vasospastic angina (VSA) resuscitated from lethal ventricular arrhythmia. Background The prognosis of VSA is known to be good with medication; however, ventricular arrhythmia and cardiopulmonary arrest are rare but life-threatening complications of this disease. The ICD is a proven modality for patients with ventricular arrhythmia, but the clinical implications in this population remain to be elucidated. Methods We conducted a retrospective, observational, multicenter study involving patients with an ICD due to documented ventricular arrhythmia and VSA diagnosed by acetylcholine provocation test. All patients were followed up for appropriate ICD therapy, sudden cardiac arrest, or death from all causes. Results Twenty-three patients were included in the present study and completely followed up. All patients are still alive. During a follow-up of 2.9 years (median 2.1 years), 4 ventricular fibrillations and 1 episode of pulseless electrical activity occurred in 5 patients (21.7%). There were no statistically significant differences in patient characteristics between the recurrence and nonrecurrence groups, including medication, smoking status, and whether the patient was or was not free of symptoms after ICD implantation. Conclusions Patients with VSA and lethal ventricular arrhythmia are a population at high risk for recurrence of cardiopulmonary arrest, and there is no reliable indicator for predicting recurrence of ventricular arrhythmia. Insertion of an ICD with medication for VSA is appropriate for this high-risk population.