Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared with multiple sclerosis

Background: Multiple sclerosis (MS) and neuromyelitis optica (NMO) both affect spinal cord with notable differences in pathology. Objective: Determine the utility of diffusion tensor imaging (DTI) to differentiate the spinal cord lesions of NMO from MS within and outside T2 lesions. Methods: Subject...

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Bibliographic Details
Published in:Multiple sclerosis 2012-09, Vol.18 (9), p.1259-1268
Main Authors: Klawiter, Eric C, Xu, Junqian, Naismith, Robert T, Benzinger, Tammie LS, Shimony, Joshua S, Lancia, Samantha, Snyder, Abraham Z, Trinkaus, Kathryn, Song, Sheng-Kwei, Cross, Anne H
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diffusion Tensor Imaging
Female
Humans
Male
Medical sciences
Middle Aged
Multiple Sclerosis - pathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nerve Degeneration
Neurology
Neuromyelitis Optica - pathology
Predictive Value of Tests
Spinal Cord - pathology
Young Adult
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Summary:Background: Multiple sclerosis (MS) and neuromyelitis optica (NMO) both affect spinal cord with notable differences in pathology. Objective: Determine the utility of diffusion tensor imaging (DTI) to differentiate the spinal cord lesions of NMO from MS within and outside T2 lesions. Methods: Subjects greater than or equal to 12 months from a clinical episode of transverse myelitis underwent a novel transaxial cervical spinal cord DTI sequence. Ten subjects with NMO, 10 with MS and 10 healthy controls were included. Results: Within T2 affected white matter regions, radial diffusivity was increased in both NMO and MS compared with healthy controls (p
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458512436593