The neural crest in vertebrate evolution

Vertebrates belong to the group of chordates characterized by a dorsal neural tube and an anteroposterior axis, the notochord. They are the only chordates to possess an embryonic and pluripotent structure associated with their neural primordium, the neural crest (NC). The NC is at the origin of mult...

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Bibliographic Details
Published in:Current opinion in genetics & development 2012-08, Vol.22 (4), p.381-389
Main Authors: Le Douarin, Nicole M, Dupin, Elisabeth
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Body Patterning
Cell Lineage
Humans
Medical Education
Neural Crest - cytology
Vertebrates - embryology
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Summary:Vertebrates belong to the group of chordates characterized by a dorsal neural tube and an anteroposterior axis, the notochord. They are the only chordates to possess an embryonic and pluripotent structure associated with their neural primordium, the neural crest (NC). The NC is at the origin of multiple cell types and plays a major role in the construction of the head, which has been an important asset in the evolutionary success of vertebrates. We discuss here the contribution of the rostral domain of the NC to craniofacial skeletogenesis. Moreover, recent data show that cephalic NC cells regulate the activity of secondary brain organizers, hence being critical for preotic brain development, a role that had not been suspected before.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2012.06.001