Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6

Abstract Cytokines, and specifically interleukin 6 (IL-6) and interleukin 8 (IL-8), have been associated with the pathogenesis of endometriosis. We studied serum concentrations of IL-6 and IL-8 in patients with deep infiltrating endometriosis (DIE) or ovarian endometriomas (OE), but no other forms o...

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Bibliographic Details
Published in:Journal of reproductive immunology 2012-09, Vol.95 (1), p.80-86
Main Authors: Carmona, Francisco, Chapron, Charles, Martínez-Zamora, María-Ángeles, Santulli, Pietro, Rabanal, Aintzane, Martínez-Florensa, Mario, Lozano, Francisco, Balasch, Juan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Case-Control Studies
Deep infiltrating endometriosis
Endometriosis
Endometriosis - blood
Endometriosis - diagnosis
Endometriosis - immunology
Female
Humans
Interleukin 6
Interleukin 8
Interleukin-6 - blood
Interleukin-6 - immunology
Interleukin-8 - blood
Interleukin-8 - immunology
Obstetrics and Gynecology
Ovarian Diseases - blood
Ovarian Diseases - diagnosis
Ovarian Diseases - immunology
Ovarian endometriomas
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Summary:Abstract Cytokines, and specifically interleukin 6 (IL-6) and interleukin 8 (IL-8), have been associated with the pathogenesis of endometriosis. We studied serum concentrations of IL-6 and IL-8 in patients with deep infiltrating endometriosis (DIE) or ovarian endometriomas (OE), but no other forms of associated endometriosis disease type. We carried out a case–control study including 19 patients with OE alone (OE group), 14 patients with DIE alone (DIE group) and 24 healthy patients without endometriosis (C group). Serum concentrations of IL-6 and IL-8 were measured in the three groups of patients. Serum levels of both IL-6 and IL-8 were significantly higher in the OE group. A high positive correlation was found between serum IL-6 and IL-8 levels in the OE group but not in the DIE and C groups. Serum IL-8 alone achieved the highest predictive value of the presence of OE (adjusted OR: 1.44; sensitivity: 78.2%; specificity: 76.2%). The combination of IL-6 and IL-8 levels did not significantly improve the discrimination between subjects with OE and those with DIE over that of IL-8. OE but not DIE are associated with increased serum levels of IL-6 and IL-8, and thus these may become useful tools for discriminating OE alone from DIE.
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2012.06.001