Interleukin-10 and Interleukin-10–Receptor Defects in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other...

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Bibliographic Details
Published in:Current allergy and asthma reports 2012-10, Vol.12 (5), p.373-379
Main Authors: Shah, Neil, Kammermeier, Jochen, Elawad, Mamoun, Glocker, Erik-Oliver
Format: Article
Language:English
Subjects:
Allergology
Diagnosis, Differential
Enterocolitis - immunology
Female
Gastrointestinal Tract - immunology
Hematopoietic Stem Cell Transplantation
Humans
Immune Deficiency and Dysregulation (DP Huston
Inflammatory bowel disease
Inflammatory Bowel Diseases - diagnosis
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - therapy
Interferon-gamma - metabolism
Interleukin-10 - deficiency
Interleukin-10 - genetics
Interleukin-22
Interleukins - metabolism
Male
Medicine
Medicine & Public Health
Mutation
Receptors, Interleukin-10 - deficiency
Receptors, Interleukin-10 - genetics
Section Editor
Signal Transduction - genetics
STAT3 Transcription Factor - genetics
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Summary:Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other primary immunodeficiencies, IL-10 and IL-10 receptor (IL10R) deficiency present with IBD and demonstrate the sensitivity of the intestine to any changes of the immune system. Both IL-10 and IL10R deficiency cause severe early-onset enterocolitis and can be successfully treated by hematopoietic stem cell transplantation (HSCT).
ISSN:1529-7322
1534-6315
1534-6315
DOI:10.1007/s11882-012-0286-z