Nitric Oxide Delivery by Core/Shell Superparamagnetic Nanoparticle Vehicles with Enhanced Biocompatibility

We report the synthesis of Fe3O4/silica core/shell nanoparticles and their functionalization with S-nitrosothiols. These nanoparticles are of immense interest because of their nitric oxide (NO) release capabilities in human alveolar epithelial cells. Moreover, they act as large storage reservoirs of...

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Bibliographic Details
Published in:Langmuir 2012-09, Vol.28 (35), p.12879-12885
Main Authors: Zhang, X. F, Mansouri, S, Mbeh, D. A, Yahia, L’H, Sacher, E, Veres, T
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biocompatible Materials - toxicity
Biological Transport
Cell Line, Tumor
Cell Survival - drug effects
Chemistry
Colloidal state and disperse state
Drug Carriers - chemistry
Drug Carriers - toxicity
Exact sciences and technology
General and physical chemistry
Humans
Magnetite Nanoparticles - chemistry
Nitric Oxide - chemistry
Nitric Oxide - metabolism
Permeability
Physical and chemical studies. Granulometry. Electrokinetic phenomena
S-Nitrosothiols - chemistry
Silicon Dioxide - chemistry
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Summary:We report the synthesis of Fe3O4/silica core/shell nanoparticles and their functionalization with S-nitrosothiols. These nanoparticles are of immense interest because of their nitric oxide (NO) release capabilities in human alveolar epithelial cells. Moreover, they act as large storage reservoirs of NO that can be targeted magnetically to the specific site with a sustainable release of NO for up to 50 h. Such nanoparticles provide an enhancement of the biocompatibility with released NO while allowing intracellular accumulation ascribed to their small size.
ISSN:0743-7463
1520-5827
DOI:10.1021/la302357h