Dosed normobaric hypoxia as a non-medication approach of stimulation of physiological regeneration of liver parenchyma

The investigation was devoted to studying the effects of different modes of dosed normobaric hypoxia on the changes in morphometric indexes of functional activity and physiological regeneration of liver parenchyma in young rats. It was shown, that in rats exposed to hypoxic gas mixture (10% O2), the...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2012, Vol.58 (3), p.43-49
Main Authors: Berezovs'kyĭ, V Ia, Ianko, R V, Litovka, I H, Chaka, O H, Zamors'ka, T M
Format: Article
Language:eng ; ukr
Subjects:
Animals
Body Weight - drug effects
Cell Count
Cell Nucleolus - ultrastructure
Cell Nucleus - ultrastructure
Cell Size
Hepatocytes - cytology
Hepatocytes - drug effects
Histocytochemistry
Hypoxia
Image Processing, Computer-Assisted
Liver - cytology
Liver - drug effects
Liver - physiology
Male
Microscopy
Organ Size - drug effects
Oxygen - therapeutic use
Rats
Rats, Wistar
Regeneration - drug effects
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Summary:The investigation was devoted to studying the effects of different modes of dosed normobaric hypoxia on the changes in morphometric indexes of functional activity and physiological regeneration of liver parenchyma in young rats. It was shown, that in rats exposed to hypoxic gas mixture (10% O2), the amount of karyonucleus and binuclear hepatocytes, nucleocytoplasmic and nucleolar-nuclear correlation increased. The changes in these indexes appeared to be more intensive when dosed normobaric intermittent hypoxia was administered with alternation of deoxygenation and reoxygenation periods. We believe that dosed normobaric hypoxia increases the functional activity and physiological regeneration of liver parenchyma.
ISSN:2522-9028
2522-9036
DOI:10.15407/fz58.03.043