Bisphosphonate therapy for painless fracture: change of HSAN 1 clinical course with biphosphonate and Vitamin D therapy

Hereditary Sensory and Autonomic Neuropathies comprise a set of 5 rare neurologic conditions, little known to radiologists as the neurologic and skin abnormalities precede the radiographic changes by months or even years. We report a Caucasian patient with a clinical history of HSAN, most consistent...

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Bibliographic Details
Published in:Journal of musculoskeletal & neuronal interactions 2012-09, Vol.12 (3), p.165-173
Main Authors: Marik, I A, Marikova, A, Hudakova, O, Samuels, M E, Kozlowski, K S
Format: Article
Language:English
Subjects:
Alendronate - therapeutic use
Cholecalciferol - therapeutic use
Diphosphonates - therapeutic use
Female
Fractures, Bone - drug therapy
Fractures, Bone - etiology
Hereditary Sensory and Autonomic Neuropathies - complications
Hereditary Sensory and Autonomic Neuropathies - drug therapy
Hereditary Sensory and Autonomic Neuropathies - physiopathology
Humans
Vitamin D - therapeutic use
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Summary:Hereditary Sensory and Autonomic Neuropathies comprise a set of 5 rare neurologic conditions, little known to radiologists as the neurologic and skin abnormalities precede the radiographic changes by months or even years. We report a Caucasian patient with a clinical history of HSAN, most consistent with subtype 1, whose progressive, destructive bone changes of the foot were not only controlled but to a degree reversed by the administration of bisphosphonates (Alendronate ) and vitamin D (Colecalciferol). The authors believe that combined bisphosphonate and vitamin D therapy is the treatment of choice for progressive bony changes in HSAN1. This therapy may be beneficial in other neuropathic osteoarthropathies and possibly osteolytic bone disorders.
ISSN:1108-7161