Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs

Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydroge...

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Bibliographic Details
Published in:CrystEngComm 2012-01, Vol.14 (7), p.2377-2380
Main Authors: Weyna, David R., Cheney, Miranda L., Shan, Ning, Hanna, Mazen, Wojtas, Łukasz, Zaworotko, Michael J.
Format: Article
Language:English
Subjects:
Crystals
Hydrogen bonding
Hydrogen bonds
Organic solids
Pharmaceuticals
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Summary:Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.
ISSN:1466-8033
1466-8033
DOI:10.1039/C2CE06574F