Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s...

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Bibliographic Details
Published in:RSC advances 2011-01, Vol.1 (5), p.758-760
Main Authors: Nagaki, Aiichiro, Imai, Keita, Kim, Heejin, Yoshida, Jun-ichi
Format: Article
Language:English
Subjects:
Microreactors
Reactors
Synthesis
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Summary:Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.
ISSN:2046-2069
2046-2069
DOI:10.1039/c1ra00377a