Simultaneous Determination of Caffeine and Acetylsalicylic Acid in Pharmaceutical Formulations Using a Boron-Doped Diamond Film Electrode by Differential Pulse Voltammetry

This work presents a simple, fast and low‐cost method for simultaneous determination of acetylsalicylic acid (ASA), without alkaline hydrolysis and caffeine (CF) in pharmaceutical formulations using a boron‐doped diamond as the working electrode through differential pulse voltammetry. A good repeata...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2012-05, Vol.24 (5), p.1141-1146
Main Authors: Faria, Eric Oliveira, Lopes Junior, Antônio Carlos Viera, Souto, Dênio Emanuel Pires, Leite, Fernando Roberto Figueiredo, Damos, Flávio Santos, de Cássia Silva Luz, Rita, dos Santos, Alexandre Soares, Franco, Diego Leoni, dos Santos, Wallans Torres Pio
Format: Article
Language:English
Subjects:
Acetylsalicylic acid
Analytical methods
Boron-doped diamond electrode
Caffeine
Calibration
Electrodes
Formulations
Pharmaceuticals
Standard deviation
Voltammetry
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Summary:This work presents a simple, fast and low‐cost method for simultaneous determination of acetylsalicylic acid (ASA), without alkaline hydrolysis and caffeine (CF) in pharmaceutical formulations using a boron‐doped diamond as the working electrode through differential pulse voltammetry. A good repeatability was reached for 20 measurements, with a low relative standard deviation of less than 1.0 %. The calibration curves presented a great linear correlation coefficient for both drugs (R=0.999) with a limit of detection of 1.6×10−7 mol L−1 for CF and 2.3×10−7 mol L−1 for ASA. The system was validated in comparison with the official method.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201200018