Water dispersible pH-responsive chitosan nanogels modified with biocompatible crosslinking-agents

Chitosan nanoparticles were obtained by crosslinking with two biocompatible dicarboxylic acids: polyethylene glycol dicarboxylic acid and tartaric acid. The water-in-oil (W/O) microemulsion method yielded particle sizes around 10–15 nm in the dried state (TEM) and 200–700 nm in the swollen state (QE...

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Bibliographic Details
Published in:Polymer (Guilford) 2012-07, Vol.53 (15), p.3107-3116
Main Authors: Pujana, Maite Arteche, Pérez-Álvarez, Leyre, Cesteros Iturbe, L. Carlos, Katime, Issa
Format: Article
Language:English
Subjects:
Applied sciences
Biocompatibility
Chitosan
Crosslinking
Dicarboxylic acids
electrostatic interactions
Exact sciences and technology
Nanocomposites
Nanogel
Nanomaterials
Nanoparticles
Nanostructure
Natural polymers
pH-responsive
Physicochemistry of polymers
polyethylene glycol
Starch and polysaccharides
tartaric acid
water solubility
zeta potential
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Summary:Chitosan nanoparticles were obtained by crosslinking with two biocompatible dicarboxylic acids: polyethylene glycol dicarboxylic acid and tartaric acid. The water-in-oil (W/O) microemulsion method yielded particle sizes around 10–15 nm in the dried state (TEM) and 200–700 nm in the swollen state (QELS) from commercial chitosan. All the synthesized nanogels showed improved water solubility and most of them were stable at physiological pH. QELS studies revealed the influence of the hydrophilic character and flexibility of the crosslinker on the swelling behaviour of the nanogels. The nanoparticles showed a pH-sensitive volume transition that was consistent with the pKa of chitosan. The collected zeta potential data corroborated the electrostatic repulsion mechanism responsible for the pH-responsive behaviour. ▪
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2012.05.027