Recurrent form of neurogenic stunned myocardium: Is myocardial adrenergic receptor distribution a dynamic process?

Abstract Neurogenic stunned myocardium mediated by stress-induced catecholamine acute release is considered as the central causative mechanism of transient left ventricular dysfunction syndrome (TVLDS). Interindividual differences in both LV β-adrenergic receptor density and sympathetic innervation...

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Bibliographic Details
Published in:International journal of cardiology 2010-11, Vol.145 (2), p.237-239
Main Authors: Morel, O, Jesel, L, Cimarelli, S, Trinh, A, Ohlmann, P, Imperiale, A
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Adrenergic receptors
Age
Aged, 80 and over
Aging
Apical balloning syndrome
Biological and medical sciences
Breaking heart syndrome
Cardiology. Vascular system
Cardiovascular
Catecholamines
Coronary heart disease
Female
Heart
Humans
Innervation
Medical sciences
Myocardial infarction
Myocardial Stunning - diagnosis
Myocardial Stunning - metabolism
Myocarditis. Cardiomyopathies
Myocardium
Receptor density
Receptors, Adrenergic, beta - metabolism
Recurrence
Syndrome
Takotsubo
Ventricle
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - metabolism
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Summary:Abstract Neurogenic stunned myocardium mediated by stress-induced catecholamine acute release is considered as the central causative mechanism of transient left ventricular dysfunction syndrome (TVLDS). Interindividual differences in both LV β-adrenergic receptor density and sympathetic innervation were proposed to explain the atypical forms of TVLDS. Whether this distribution is independent of age or may vary during ageing still remains unclear. We report a recurrent form of TLVDS characterized by two different patterns. Whilst myocardial receptor distribution or sympathetic innervation appears to follow a dynamic process, the precise determinants of these variations remain largely unknown.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2009.08.020