Anti-GQ1b-Negative Miller Fisher Syndrome After Campylobacter jejuni  Enteritis

Abstract Miller Fisher syndrome is a clinical variant of Guillain-Barré syndrome, characterized by acute-onset ophthalmoplegia, ataxia, and areflexia. It results from an immune response to a cross-reactive antigen between GQ1b ganglioside in human neurons and lipo-oligosaccharides of certain bacteri...

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Bibliographic Details
Published in:Pediatric neurology 2012-09, Vol.47 (3), p.213-215
Main Author: Lee, Kyung Yeon, MD
Format: Article
Language:English
Subjects:
Antibodies
Ataxia
Ataxia - etiology
Biological and medical sciences
Blepharoptosis - etiology
Campylobacter Infections - complications
Campylobacter Infections - microbiology
Campylobacter Infections - physiopathology
Campylobacter jejuni
Child
Diplopia - etiology
Enteritis
G(M1) Ganglioside - analogs & derivatives
G(M1) Ganglioside - immunology
Gangliosides
Gangliosides - immunology
Guillain-Barre syndrome
Humans
Immune response
Male
Malformations of the nervous system
Medical sciences
Miller Fisher Syndrome - etiology
Miller Fisher Syndrome - physiopathology
Miller-Fisher syndrome
Neurologic Examination
Neurology
Neurons
Ophthalmoplegia
Pediatrics
Reflex
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Summary:Abstract Miller Fisher syndrome is a clinical variant of Guillain-Barré syndrome, characterized by acute-onset ophthalmoplegia, ataxia, and areflexia. It results from an immune response to a cross-reactive antigen between GQ1b ganglioside in human neurons and lipo-oligosaccharides of certain bacteria, e.g., Campylobacter jejuni . Anti-GQ1b antibody is a powerful diagnostic marker for Miller Fisher syndrome. However, only a small number of anti-GQ1b-negative Miller Fisher syndrome cases are documented. A 13-year-old boy demonstrated typical clinical features of Miller Fisher syndrome 1 week after C. jejuni enteritis, but was anti-GQ1b and anti-GM1b antibody-negative.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2012.04.024