Is there an association between autoimmunity and endometriosis?

Abstract Endometriosis is a benign gynecologic disorder that affects 5–10% of women of reproductive age worldwide. It is characterized by the presence of ectopic endometrial cells and stroma in various locations outside the endometrium. In some of these women there are also a chronic local inflammat...

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Bibliographic Details
Published in:Autoimmunity reviews 2012-09, Vol.11 (11), p.806-814
Main Authors: Eisenberg, Vered H, Zolti, Mati, Soriano, David
Format: Article
Language:English
Subjects:
Age
Allergy and Immunology
Apoptosis
Autoantibodies
Autoimmune diseases
Autoimmunity
Benign
Cytokines
Endometriosis
Endometrium
Etiology
Geographical variations
Immunity
Immunomodulation
Infertility
Inflammation
Literature reviews
Pregnancy loss
Stroma
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Summary:Abstract Endometriosis is a benign gynecologic disorder that affects 5–10% of women of reproductive age worldwide. It is characterized by the presence of ectopic endometrial cells and stroma in various locations outside the endometrium. In some of these women there are also a chronic local inflammatory process and presence of autoantibodies. It is not known whether this process is part of the etiology or is a secondary response to the ectopic cells. Furthermore, endometriosis shares similarities with several autoimmune diseases, which include elevated levels of cytokines, decreased apoptosis, and cell-mediated abnormalities. Our aim in this paper was to review the association between autoimmunity and endometriosis. For this purpose we conducted a thorough literature review in the MEDLINE/PubMed database using the keyword endometriosis crossed with: autoimmune disease, autoimmune diseases, autoimmunity, autoantibodies, immunity, immune-modulation, endometrial antibodies, etc.
ISSN:1568-9972
1568-9972
DOI:10.1016/j.autrev.2012.01.005