Phenoptosis in yeasts

The current view on phenoptosis and apoptosis as genetic programs aimed at eliminating potentially dangerous organisms and cells, respectively, is given. Special emphasis is placed on apoptosis (phenoptosis) in yeasts: intracellular defects and a plethora of external stimuli inducing apoptosis in ye...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2012-07, Vol.77 (7), p.761-775
Main Authors: Sukhanova, E. I., Rogov, A. G., Severin, F. F., Zvyagilskaya, R. A.
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Dangerous organisms
Life Sciences
Microbial Viability - genetics
Microbiology
Mitochondria
Mitochondrial DNA
Morphology
Review
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Signal Transduction - genetics
Time Factors
Yeast
Yeasts
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Summary:The current view on phenoptosis and apoptosis as genetic programs aimed at eliminating potentially dangerous organisms and cells, respectively, is given. Special emphasis is placed on apoptosis (phenoptosis) in yeasts: intracellular defects and a plethora of external stimuli inducing apoptosis in yeasts; distinctive morphological and biochemical hallmarks accompanying apoptosis in yeasts; pro- and antiapoptotic factors involved in yeast apoptosis signaling; consecutive stages of apoptosis from external stimulus to the cell death; a prominent role of mitochondria and other organelles in yeast apoptosis; possible pathways for release of apoptotic factors from the intermembrane mitochondrial space into the cytosol are described. Using some concrete examples, the obvious physiological importance and expediency of altruistic death of yeast cells is shown. Poorly known aspects of yeast apoptosis and prospects for yeast apoptosis study are defined.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297912070097