A rare case of primary cutaneous plasmacytoma-like lymphoproliferative disorder following renal transplantation

Post‐transplant lymphoproliferative disorder (PTLD) is a lymphoid proliferation that develops as a complication of solid organ or bone marrow transplants. PTLD limited to the skin is very rare. Plasmacytoma‐like PTLD is an uncommon variant of monomorphic PTLD. Its presentation in the skin is extraor...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2012-07, Vol.39 (7), p.685-689
Main Authors: Molina-Ruiz, Ana M., Pulpillo, Águeda, Lasanta, Begoña, Zulueta, Teresa, Andrades, Rocío, Requena, Luis
Format: Article
Language:English
Subjects:
Aged
Epstein-Barr virus
Humans
Immunoglobulin kappa-Chains - metabolism
Immunoproliferative diseases
kidney transplant
Kidney Transplantation
Leg
Light chains
Male
Neoplasm Proteins - metabolism
Nodules
Plasmacytoma - metabolism
Plasmacytoma - pathology
plasmacytoma-like
post-transplant lymphoproliferative disorder
posttransplant lymphoproliferative disorders
Skin
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Syndecan-1 - metabolism
Tumors
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Summary:Post‐transplant lymphoproliferative disorder (PTLD) is a lymphoid proliferation that develops as a complication of solid organ or bone marrow transplants. PTLD limited to the skin is very rare. Plasmacytoma‐like PTLD is an uncommon variant of monomorphic PTLD. Its presentation in the skin is extraordinary with very few cases reported in the literature. We report a new case of plasmacytoma‐like PTLD presenting as multiple skin nodules on the leg of a 74‐year‐old kidney transplant recipient. Histopathologic and immunohistochemical examination of one nodule revealed atypical plasmacytoid and plasmablastic cells that showed kappa light chain restriction and stained positive for CD138. Staging investigations excluded extracutaneous manifestations of the disease. This case is unusual for several reasons including involvement limited to the skin, plasmacytoid phenotype of the tumor, presentation 18 years following transplantation and Epstein–Barr virus negativity. Molina‐Ruiz AM, Pulpillo A, Lasanta B, Zulueta T, Andrades R, Requena L. A rare case of primary cutaneous plasmacytoma‐like lymphoproliferative disorder following renal transplantation.
ISSN:0303-6987
1600-0560
DOI:10.1111/j.1600-0560.2012.01919.x