Activity of telavancin compared to other agents against coagulase-negative staphylococci with different resistotypes by time kill

Abstract Among 10 coagulase-negative staphylococci, telavancin, quinupristin/dalfopristin, and tigecycline were the most potent antimicrobials. Telavancin exhibited bactericidal effect to 9 strains out of 10 tested at 4 × MIC after 24 h of exposure similar to those of vancomycin and daptomycin. By c...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2012-07, Vol.73 (3), p.287-289
Main Authors: Lin, Gengrong, Pankuch, Glenn A, Appelbaum, Peter C, Kosowska-Shick, Klaudia
Format: Article
Language:English
Subjects:
Aminoglycosides - pharmacology
Anti-Bacterial Agents - pharmacology
Bacteriology
Biological and medical sciences
Coagulase - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Infectious Disease
Infectious diseases
Internal Medicine
Medical sciences
Microbial Sensitivity Tests
Microbial Viability - drug effects
Microbiology
Miscellaneous
Staphylococcus - drug effects
Staphylococcus - enzymology
Staphylococcus aureus
Telavancin
Time Factors
Time kill
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Summary:Abstract Among 10 coagulase-negative staphylococci, telavancin, quinupristin/dalfopristin, and tigecycline were the most potent antimicrobials. Telavancin exhibited bactericidal effect to 9 strains out of 10 tested at 4 × MIC after 24 h of exposure similar to those of vancomycin and daptomycin. By contrast, linezolid was mainly bacteriostatic and teicoplanin was bactericidal to 7 strains tested at 4 × MIC after 24 h.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2012.04.003