BNNT-Mediated Irreversible Electroporation: Its Potential on Cancer Cells

Irreversible lethal electroporation (IRE) is a new non-thermal ablation modality that uses short pulses of high amplitude static electric fields (up 1000 V/cm) to create irreversible pores in the cell membrane, thus, causing cell death. Recently, IRE has emerged as a promising clinical modality for...

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Bibliographic Details
Published in:Technology in cancer research & treatment 2012-10, Vol.11 (5), p.459-465
Main Authors: Raffa, V., Riggio, C., Smith, M. W., Jordan, K. C., Cao, W., Cuschieri, A.
Format: Article
Language:English
Subjects:
Algorithms
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biological and medical sciences
Boron Compounds - chemistry
Boron Compounds - pharmacology
Cell Survival - drug effects
Electromagnetic Fields
Electroporation
HeLa Cells
Humans
Medical sciences
Models, Biological
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Nanotubes - chemistry
Nanotubes - ultrastructure
Tumors
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Summary:Irreversible lethal electroporation (IRE) is a new non-thermal ablation modality that uses short pulses of high amplitude static electric fields (up 1000 V/cm) to create irreversible pores in the cell membrane, thus, causing cell death. Recently, IRE has emerged as a promising clinical modality for cancer disease treatment. Here, we investigated the responses of tumour human HeLa cells when subjected to IRE in the presence of BNNTs. These consist of tiny tubes of B and N atoms (arranged in hexagons) with diameters ranging from a 1 to 3 nanometres and lengths
ISSN:1533-0346
1533-0338
DOI:10.7785/tcrt.2012.500258