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Intravenous Immunoglobulin for Repeated IVF Failure and Unexplained Infertility
Problem We set out to determine whether intravenous immunoglobulin (IVIG) improves in vitro fertilization (IVF) success rates in women with a difficult history of multiple (≥2) prior IVF failures and /or ‘unexplained’ infertility. Method of study A total of 229 women with multiple IVF failures (3.3 ...
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| Published in: | American journal of reproductive immunology (1989) 2012-09, Vol.68 (3), p.218-225 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c5069-7100e491fa5bcb42fc70a1fce720066ddb5fc577adece6952c5d048071240e203 |
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| cites | cdi_FETCH-LOGICAL-c5069-7100e491fa5bcb42fc70a1fce720066ddb5fc577adece6952c5d048071240e203 |
| container_end_page | 225 |
| container_issue | 3 |
| container_start_page | 218 |
| container_title | American journal of reproductive immunology (1989) |
| container_volume | 68 |
| creator | Virro, Michael R. Winger, Edward E. Reed, Jane L. |
| description | Problem
We set out to determine whether intravenous immunoglobulin (IVIG) improves in vitro fertilization (IVF) success rates in women with a difficult history of multiple (≥2) prior IVF failures and /or ‘unexplained’ infertility.
Method of study
A total of 229 women with multiple IVF failures (3.3 ± 2.1) and/or unexplained infertility (3.8 ± 2.7 years) were given IVIG on the day of egg retrieval, and the subsequent IVF success rates were compared with published success rates from the Canadian database (CARTR).
Results
The pregnancy rate per IVIG‐treated cycle was 60.3% (138/229), and the live birth rate per IVIG‐treated cycle was 40.2% (92/229). This is a significantly higher success rate compared to the Canadian average (30% live birth rate; CARTR statistics from 2010; P = 0.0012). In cases where a single embryo was transferred, pregnancy rate using IVIG was almost twofold the CARTR pregnancy rate [(61%(20/33) to 34.9% (428/1225)]. In cases where two high quality (≥Grade 3) day 5 blastocysts were transferred, nearly a 100% pregnancy rate was achieved using IVIG (30/31).
Conclusion
IVIG may be a useful treatment option for patients with previous IVF failure and/ or unexplained infertility. The data confirm previously published studies at other centers. |
| doi_str_mv | 10.1111/j.1600-0897.2012.01169.x |
| format | article |
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We set out to determine whether intravenous immunoglobulin (IVIG) improves in vitro fertilization (IVF) success rates in women with a difficult history of multiple (≥2) prior IVF failures and /or ‘unexplained’ infertility.
Method of study
A total of 229 women with multiple IVF failures (3.3 ± 2.1) and/or unexplained infertility (3.8 ± 2.7 years) were given IVIG on the day of egg retrieval, and the subsequent IVF success rates were compared with published success rates from the Canadian database (CARTR).
Results
The pregnancy rate per IVIG‐treated cycle was 60.3% (138/229), and the live birth rate per IVIG‐treated cycle was 40.2% (92/229). This is a significantly higher success rate compared to the Canadian average (30% live birth rate; CARTR statistics from 2010; P = 0.0012). In cases where a single embryo was transferred, pregnancy rate using IVIG was almost twofold the CARTR pregnancy rate [(61%(20/33) to 34.9% (428/1225)]. In cases where two high quality (≥Grade 3) day 5 blastocysts were transferred, nearly a 100% pregnancy rate was achieved using IVIG (30/31).
Conclusion
IVIG may be a useful treatment option for patients with previous IVF failure and/ or unexplained infertility. The data confirm previously published studies at other centers.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/j.1600-0897.2012.01169.x</identifier><identifier>PMID: 22805355</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adult ; Blastocyst ; Blastocyst - drug effects ; Blastocyst - immunology ; blastocysts ; Data processing ; Databases, Factual ; embryo quality ; Embryo Transfer ; Embryos ; Female ; Fertilization ; Fertilization in Vitro ; Humans ; Immunoglobulins ; Immunoglobulins, Intravenous - administration & dosage ; Immunologic Factors - administration & dosage ; immunotherapy ; Infertility ; Infertility - drug therapy ; Infertility - immunology ; Intravenous administration ; natural killer cell ; Ovum - drug effects ; Ovum - immunology ; Pregnancy ; Pregnancy Rate ; repeat IVF failure ; Statistics ; Th1/Th2 ratio ; Treatment Failure ; unexplained infertility</subject><ispartof>American journal of reproductive immunology (1989), 2012-09, Vol.68 (3), p.218-225</ispartof><rights>2012 John Wiley & Sons A/S</rights><rights>2012 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5069-7100e491fa5bcb42fc70a1fce720066ddb5fc577adece6952c5d048071240e203</citedby><cites>FETCH-LOGICAL-c5069-7100e491fa5bcb42fc70a1fce720066ddb5fc577adece6952c5d048071240e203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22805355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Virro, Michael R.</creatorcontrib><creatorcontrib>Winger, Edward E.</creatorcontrib><creatorcontrib>Reed, Jane L.</creatorcontrib><title>Intravenous Immunoglobulin for Repeated IVF Failure and Unexplained Infertility</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem
We set out to determine whether intravenous immunoglobulin (IVIG) improves in vitro fertilization (IVF) success rates in women with a difficult history of multiple (≥2) prior IVF failures and /or ‘unexplained’ infertility.
Method of study
A total of 229 women with multiple IVF failures (3.3 ± 2.1) and/or unexplained infertility (3.8 ± 2.7 years) were given IVIG on the day of egg retrieval, and the subsequent IVF success rates were compared with published success rates from the Canadian database (CARTR).
Results
The pregnancy rate per IVIG‐treated cycle was 60.3% (138/229), and the live birth rate per IVIG‐treated cycle was 40.2% (92/229). This is a significantly higher success rate compared to the Canadian average (30% live birth rate; CARTR statistics from 2010; P = 0.0012). In cases where a single embryo was transferred, pregnancy rate using IVIG was almost twofold the CARTR pregnancy rate [(61%(20/33) to 34.9% (428/1225)]. In cases where two high quality (≥Grade 3) day 5 blastocysts were transferred, nearly a 100% pregnancy rate was achieved using IVIG (30/31).
Conclusion
IVIG may be a useful treatment option for patients with previous IVF failure and/ or unexplained infertility. The data confirm previously published studies at other centers.</description><subject>Adult</subject><subject>Blastocyst</subject><subject>Blastocyst - drug effects</subject><subject>Blastocyst - immunology</subject><subject>blastocysts</subject><subject>Data processing</subject><subject>Databases, Factual</subject><subject>embryo quality</subject><subject>Embryo Transfer</subject><subject>Embryos</subject><subject>Female</subject><subject>Fertilization</subject><subject>Fertilization in Vitro</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - administration & dosage</subject><subject>Immunologic Factors - administration & dosage</subject><subject>immunotherapy</subject><subject>Infertility</subject><subject>Infertility - drug therapy</subject><subject>Infertility - immunology</subject><subject>Intravenous administration</subject><subject>natural killer cell</subject><subject>Ovum - drug effects</subject><subject>Ovum - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>repeat IVF failure</subject><subject>Statistics</subject><subject>Th1/Th2 ratio</subject><subject>Treatment Failure</subject><subject>unexplained infertility</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkE1v1DAQhi1ERT_gL6AcuSQdO7GdHDhUK7YEVbSqKHCzHGeCvDjO4iRl99_XYcue64tHnuedkR9CEgoZjedyk1EBkEJZyYwBZRlQKqps94qcHRuvYw2FSGUB5Sk5H8cNQHzP5RtyylgJPOf8jNzWfgr6Ef0wj0nd97MffrmhmZ31STeE5B63qCdsk_r7Ollr6-aAifZt8uBxt3Xa-qXnOwyTdXbavyUnnXYjvnu-L8jD-tO31ef05va6Xl3dpIaDqFJJAbCoaKd5Y5qCdUaCpp1ByQCEaNuGd4ZLqVs0KCrODG-hKEFSVgAyyC_Ih8PcbRj-zDhOqrejQee0x_gVRSEvRZzE6EvQvOC8hCqi5QE1YRjHgJ3aBtvrsI-QWsyrjVoEq0WwWsyrf-bVLkbfP2-Zmx7bY_C_6gh8PAB_rcP9iwerqy_1UsV8esjbccLdMa_DbyVkLrn68fValfLnihfsTvH8CdDyn_I</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Virro, Michael R.</creator><creator>Winger, Edward E.</creator><creator>Reed, Jane L.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201209</creationdate><title>Intravenous Immunoglobulin for Repeated IVF Failure and Unexplained Infertility</title><author>Virro, Michael R. ; Winger, Edward E. ; Reed, Jane L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5069-7100e491fa5bcb42fc70a1fce720066ddb5fc577adece6952c5d048071240e203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Blastocyst</topic><topic>Blastocyst - drug effects</topic><topic>Blastocyst - immunology</topic><topic>blastocysts</topic><topic>Data processing</topic><topic>Databases, Factual</topic><topic>embryo quality</topic><topic>Embryo Transfer</topic><topic>Embryos</topic><topic>Female</topic><topic>Fertilization</topic><topic>Fertilization in Vitro</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins, Intravenous - administration & dosage</topic><topic>Immunologic Factors - administration & dosage</topic><topic>immunotherapy</topic><topic>Infertility</topic><topic>Infertility - drug therapy</topic><topic>Infertility - immunology</topic><topic>Intravenous administration</topic><topic>natural killer cell</topic><topic>Ovum - drug effects</topic><topic>Ovum - immunology</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>repeat IVF failure</topic><topic>Statistics</topic><topic>Th1/Th2 ratio</topic><topic>Treatment Failure</topic><topic>unexplained infertility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Virro, Michael R.</creatorcontrib><creatorcontrib>Winger, Edward E.</creatorcontrib><creatorcontrib>Reed, Jane L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Virro, Michael R.</au><au>Winger, Edward E.</au><au>Reed, Jane L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous Immunoglobulin for Repeated IVF Failure and Unexplained Infertility</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2012-09</date><risdate>2012</risdate><volume>68</volume><issue>3</issue><spage>218</spage><epage>225</epage><pages>218-225</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem
We set out to determine whether intravenous immunoglobulin (IVIG) improves in vitro fertilization (IVF) success rates in women with a difficult history of multiple (≥2) prior IVF failures and /or ‘unexplained’ infertility.
Method of study
A total of 229 women with multiple IVF failures (3.3 ± 2.1) and/or unexplained infertility (3.8 ± 2.7 years) were given IVIG on the day of egg retrieval, and the subsequent IVF success rates were compared with published success rates from the Canadian database (CARTR).
Results
The pregnancy rate per IVIG‐treated cycle was 60.3% (138/229), and the live birth rate per IVIG‐treated cycle was 40.2% (92/229). This is a significantly higher success rate compared to the Canadian average (30% live birth rate; CARTR statistics from 2010; P = 0.0012). In cases where a single embryo was transferred, pregnancy rate using IVIG was almost twofold the CARTR pregnancy rate [(61%(20/33) to 34.9% (428/1225)]. In cases where two high quality (≥Grade 3) day 5 blastocysts were transferred, nearly a 100% pregnancy rate was achieved using IVIG (30/31).
Conclusion
IVIG may be a useful treatment option for patients with previous IVF failure and/ or unexplained infertility. The data confirm previously published studies at other centers.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>22805355</pmid><doi>10.1111/j.1600-0897.2012.01169.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2012-09, Vol.68 (3), p.218-225 |
| issn | 1046-7408 1600-0897 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1038606621 |
| source | Wiley |
| subjects | Adult Blastocyst Blastocyst - drug effects Blastocyst - immunology blastocysts Data processing Databases, Factual embryo quality Embryo Transfer Embryos Female Fertilization Fertilization in Vitro Humans Immunoglobulins Immunoglobulins, Intravenous - administration & dosage Immunologic Factors - administration & dosage immunotherapy Infertility Infertility - drug therapy Infertility - immunology Intravenous administration natural killer cell Ovum - drug effects Ovum - immunology Pregnancy Pregnancy Rate repeat IVF failure Statistics Th1/Th2 ratio Treatment Failure unexplained infertility |
| title | Intravenous Immunoglobulin for Repeated IVF Failure and Unexplained Infertility |
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