Primary Nasal Histiocytic Sarcoma of Macrophage–Myeloid Cell Type in a Cat

A 16-year-old neutered male Burmese cat was presented with a locally invasive nasal mass. The cytological and histological findings on incisional biopsy of this mass were suggestive of histiocytic sarcoma. Tumour cells expressed CD18, major histocompatibility complex class II, lysozyme and alpha-nap...

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Bibliographic Details
Published in:Journal of comparative pathology 2012-08, Vol.147 (2-3), p.209-213
Main Authors: Wong, V.M., Snyman, H.N., Ackerley, C., Bienzle, D.
Format: Article
Language:English
Subjects:
acetates
Acetic acid
Animals
Autopsy
Biomarkers, Tumor - metabolism
Biopsy
Bone marrow
Bone Marrow Cells - metabolism
Bone Marrow Cells - pathology
Bone Marrow Neoplasms - metabolism
Bone Marrow Neoplasms - secondary
Bone Marrow Neoplasms - veterinary
cat
Cat Diseases - metabolism
Cat Diseases - pathology
Cats
CD11c antigen
CD18 antigen
CD3 antigen
E-Cadherin
esterase
Fatal Outcome
Histiocytic Sarcoma - metabolism
Histiocytic Sarcoma - pathology
Histiocytic Sarcoma - veterinary
immunohistochemistry
Invasiveness
Lysozyme
macrophage
Macrophages - metabolism
Macrophages - pathology
Major histocompatibility complex
Male
Metastases
metastasis
nasal cavity
necropsy
Neoplasia
Nose
Nose Neoplasms - metabolism
Nose Neoplasms - pathology
Nose Neoplasms - veterinary
Orchiectomy - veterinary
round cell tumour
Sarcoma
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Description
Summary:A 16-year-old neutered male Burmese cat was presented with a locally invasive nasal mass. The cytological and histological findings on incisional biopsy of this mass were suggestive of histiocytic sarcoma. Tumour cells expressed CD18, major histocompatibility complex class II, lysozyme and alpha-naphthyl acetate esterase; and lacked expression of CD3, CD79a, CD1a, CD1b, calprotectin, CD11c and E-cadherin. These findings are consistent with a myeloid–macrophage lineage. Metastasis to the bone marrow was present on necropsy examination. Histiocytic sarcoma should be considered in cats presented with primary round cell neoplasia of the nasal cavity.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2012.01.015